Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis

Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis

BackgroundGut microbiota (GM) and metabolic alterations play pivotal roles in lung cancer (LC) development and host genetic variations are known to contribute to LC susceptibility by modulating the GM. However, the causal links among GM, metabolite, host genes, and LC remain to be fully delineated.M...

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Bibliographic Details
Main Authors: Yizhao Du, Qin Wang, Zongmei Zheng, Hailun Zhou, Yang Han, Ao Qi, Lijing Jiao, Yabin Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Nutrition
Subjects:
lung cancer
gut microbiota
metabolite
Mendelian randomization
gene
mediation analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1425802/full
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