The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men
Background and Aims: Aging causes changes in health status, including endothelial dysfunction, angiogenesis disorder, and an increase in the prevalence of diseases. Due to the growing trend of aging in the world, it is important to prevent the occurrence of related problems in this period. Sports ac...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Birjand University of Medical Sciences and Health Services
2024-08-01
|
| Series: | مجله دانشگاه علوم پزشکی بیرجند |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/article-1-3351-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850100950128132096 |
|---|---|
| author | Amir Delshad Fateme Talashan |
| author_facet | Amir Delshad Fateme Talashan |
| author_sort | Amir Delshad |
| collection | DOAJ |
| description | Background and Aims: Aging causes changes in health status, including endothelial dysfunction, angiogenesis disorder, and an increase in the prevalence of diseases. Due to the growing trend of aging in the world, it is important to prevent the occurrence of related problems in this period. Sports activity can be a positive factor in stimulating the angiogenesis process in physiological conditions and even in pathological conditions. This study aimed to investigate the effect of two types of aerobic and combined training (aerobic-strength) on the vascular endothelial growth factor (VEGF) and tissue inhibitor metalloproteinase (TIMP-1) factors in elderly men.
Materials and Methods: In this quasi-experimental study, 30 elderly men with an average age of 62.36 ± 1.28 years were selected. These individuals were randomly and equally divided into three groups: aerobic, combined, and control based on body mass index and maximum oxygen consumption. The exercises were done for 8 weeks. Aerobic exercises were performed with 60-70% of heart rate reserve. The combined exercises were done with the same heart rate reserve as the aerobic exercise but with half the duration, and resistance exercise with 60-75% one-repetition maximum. Combined exercises consisted of both aerobic and strength exercises in one day, starting with strength training followed by aerobic exercise. Blood samples were collected to measure the serum levels of VEGF and TIMP-1 before the first and after the last session in a fasting state. The measurements were taken using the ELISA method. To compare the means within and between groups, analysis of covariance and paired t-tests were used with a significance level of P ≤ 0.05.
Results: Aerobic exercises led to a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. Combined exercises also caused a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. According to post-test results, VEGF significantly increased, and TIMP-1 significantly decreased in both aerobic and combined groups compared to pre-test results.
Conclusion: Aerobic and combined exercise caused an increase in VEGF, a decrease in TIMP-1, and an improvement in the angiogenesis process in the elderly men. |
| format | Article |
| id | doaj-art-05c991e9ddef4e798f8b67a036e79294 |
| institution | DOAJ |
| issn | 1607-2197 2423-6152 |
| language | fas |
| publishDate | 2024-08-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj-art-05c991e9ddef4e798f8b67a036e792942025-08-20T02:40:10ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522024-08-01312161171The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly menAmir Delshad0Fateme Talashan1 Department of Sports Sciences, Faculty of Literature and Human Sciences, University of Qom, Qom, Iran Department of Sports Sciences, School of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran Background and Aims: Aging causes changes in health status, including endothelial dysfunction, angiogenesis disorder, and an increase in the prevalence of diseases. Due to the growing trend of aging in the world, it is important to prevent the occurrence of related problems in this period. Sports activity can be a positive factor in stimulating the angiogenesis process in physiological conditions and even in pathological conditions. This study aimed to investigate the effect of two types of aerobic and combined training (aerobic-strength) on the vascular endothelial growth factor (VEGF) and tissue inhibitor metalloproteinase (TIMP-1) factors in elderly men. Materials and Methods: In this quasi-experimental study, 30 elderly men with an average age of 62.36 ± 1.28 years were selected. These individuals were randomly and equally divided into three groups: aerobic, combined, and control based on body mass index and maximum oxygen consumption. The exercises were done for 8 weeks. Aerobic exercises were performed with 60-70% of heart rate reserve. The combined exercises were done with the same heart rate reserve as the aerobic exercise but with half the duration, and resistance exercise with 60-75% one-repetition maximum. Combined exercises consisted of both aerobic and strength exercises in one day, starting with strength training followed by aerobic exercise. Blood samples were collected to measure the serum levels of VEGF and TIMP-1 before the first and after the last session in a fasting state. The measurements were taken using the ELISA method. To compare the means within and between groups, analysis of covariance and paired t-tests were used with a significance level of P ≤ 0.05. Results: Aerobic exercises led to a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. Combined exercises also caused a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. According to post-test results, VEGF significantly increased, and TIMP-1 significantly decreased in both aerobic and combined groups compared to pre-test results. Conclusion: Aerobic and combined exercise caused an increase in VEGF, a decrease in TIMP-1, and an improvement in the angiogenesis process in the elderly men.http://journal.bums.ac.ir/article-1-3351-en.pdfaerobic trainingcombined trainingelderly mentimp-1vegf |
| spellingShingle | Amir Delshad Fateme Talashan The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men مجله دانشگاه علوم پزشکی بیرجند aerobic training combined training elderly men timp-1 vegf |
| title | The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| title_full | The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| title_fullStr | The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| title_full_unstemmed | The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| title_short | The serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| title_sort | serum changes of vascular endothelial growth factor and tissue inhibitor metalloproteinase factors after a period of combined and aerobic physical activity in elderly men |
| topic | aerobic training combined training elderly men timp-1 vegf |
| url | http://journal.bums.ac.ir/article-1-3351-en.pdf |
| work_keys_str_mv | AT amirdelshad theserumchangesofvascularendothelialgrowthfactorandtissueinhibitormetalloproteinasefactorsafteraperiodofcombinedandaerobicphysicalactivityinelderlymen AT fatemetalashan theserumchangesofvascularendothelialgrowthfactorandtissueinhibitormetalloproteinasefactorsafteraperiodofcombinedandaerobicphysicalactivityinelderlymen AT amirdelshad serumchangesofvascularendothelialgrowthfactorandtissueinhibitormetalloproteinasefactorsafteraperiodofcombinedandaerobicphysicalactivityinelderlymen AT fatemetalashan serumchangesofvascularendothelialgrowthfactorandtissueinhibitormetalloproteinasefactorsafteraperiodofcombinedandaerobicphysicalactivityinelderlymen |