Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths
ABSTRACT Background The majority of cystine uroliths occur in intact male dogs. Androgen‐dependent (Type III) cystinuria is considered the most common cause. Objectives Identify dog breeds in which castration is likely to decrease the risk of cystine uroliths, the potential effect of delaying castra...
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Wiley
2025-05-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70110 |
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| author | Jody P. Lulich Rachael Ulrich Eva Furrow |
| author_facet | Jody P. Lulich Rachael Ulrich Eva Furrow |
| author_sort | Jody P. Lulich |
| collection | DOAJ |
| description | ABSTRACT Background The majority of cystine uroliths occur in intact male dogs. Androgen‐dependent (Type III) cystinuria is considered the most common cause. Objectives Identify dog breeds in which castration is likely to decrease the risk of cystine uroliths, the potential effect of delaying castration on cystine urolith formation, and urolith recurrence frequency. Animals Records of 5477 dogs with cystine uroliths and comparison groups without cystine uroliths (263 938 dogs with non‐cystine uroliths and 44 491 dogs from a hospital population). Methods In this case‐control study, odds ratios and 95% confidence intervals (CIs) were calculated to identify breeds where the proportion of intact males with cystine uroliths was higher than that of intact males without cystine uroliths. The proportions of intact males forming cystine uroliths before 12, 24, and 36 months of age were calculated. Cystine urolith recurrence rates were assessed by breed in male dogs. Results Dogs with cystine uroliths were 99% male. Across 60 breeds, the median proportion of male cystine urolith formers that were intact was 98% (range, 40%–100%). When compared with dogs without cystine uroliths, intact males were overrepresented in cystine urolith formers in all breeds except 8 (Akita, Belgian Malinois, Brussels Griffon, Cane Corso, Coonhound, Newfoundland, Scottish Terrier, and Silky Terrier). Diagnosis occurred before 36 months of age in 28% (n = 1328) of intact male cystine urolith formers. Cystine uroliths recurred in 5.0% (n = 255) of males; 81% (n = 207) were intact males. Conclusions and Clinical Importance Androgens likely play a role in the development of cystine uroliths across many dog breeds. |
| format | Article |
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| institution | OA Journals |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-05bc13f6a2894f349475a52335bf709c2025-08-20T01:53:49ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-05-01393n/an/a10.1111/jvim.70110Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine UrolithsJody P. Lulich0Rachael Ulrich1Eva Furrow2Department of Veterinary Clinical Sciences, College of Veterinary Medicine University of Minnesota St Paul Minnesota USADepartment of Veterinary Clinical Sciences, College of Veterinary Medicine University of Minnesota St Paul Minnesota USADepartment of Veterinary Clinical Sciences, College of Veterinary Medicine University of Minnesota St Paul Minnesota USAABSTRACT Background The majority of cystine uroliths occur in intact male dogs. Androgen‐dependent (Type III) cystinuria is considered the most common cause. Objectives Identify dog breeds in which castration is likely to decrease the risk of cystine uroliths, the potential effect of delaying castration on cystine urolith formation, and urolith recurrence frequency. Animals Records of 5477 dogs with cystine uroliths and comparison groups without cystine uroliths (263 938 dogs with non‐cystine uroliths and 44 491 dogs from a hospital population). Methods In this case‐control study, odds ratios and 95% confidence intervals (CIs) were calculated to identify breeds where the proportion of intact males with cystine uroliths was higher than that of intact males without cystine uroliths. The proportions of intact males forming cystine uroliths before 12, 24, and 36 months of age were calculated. Cystine urolith recurrence rates were assessed by breed in male dogs. Results Dogs with cystine uroliths were 99% male. Across 60 breeds, the median proportion of male cystine urolith formers that were intact was 98% (range, 40%–100%). When compared with dogs without cystine uroliths, intact males were overrepresented in cystine urolith formers in all breeds except 8 (Akita, Belgian Malinois, Brussels Griffon, Cane Corso, Coonhound, Newfoundland, Scottish Terrier, and Silky Terrier). Diagnosis occurred before 36 months of age in 28% (n = 1328) of intact male cystine urolith formers. Cystine uroliths recurred in 5.0% (n = 255) of males; 81% (n = 207) were intact males. Conclusions and Clinical Importance Androgens likely play a role in the development of cystine uroliths across many dog breeds.https://doi.org/10.1111/jvim.70110androgen dependentcalculigenetic variantSLC3A 1SLC7 A9 |
| spellingShingle | Jody P. Lulich Rachael Ulrich Eva Furrow Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths Journal of Veterinary Internal Medicine androgen dependent calculi genetic variant SLC3A 1 SLC7 A9 |
| title | Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths |
| title_full | Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths |
| title_fullStr | Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths |
| title_full_unstemmed | Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths |
| title_short | Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths |
| title_sort | epidemiological evaluation of neuter status sex and breed in dogs with cystine uroliths |
| topic | androgen dependent calculi genetic variant SLC3A 1 SLC7 A9 |
| url | https://doi.org/10.1111/jvim.70110 |
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