Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae)
The study of substances of botanical origin is fundamental for the development of new effective alternatives for the control of <i>Aedes (Stegomyia) aegypti</i> (Culicidae), a vector of arboviruses in humans. In this study, the potential of two new dillapiole derivatives, propyl ether di...
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MDPI AG
2025-04-01
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| author | Junielson Soares da Silva Ana Cristina da Silva Pinto Samara Silva de Souza Francisco Célio Maia Chaves Sabrina da Fonseca Meireles Rosalina Pinheiro Pereira Rosemary Aparecida Roque João Marcelo de Castro e Sousa Míriam Silva Rafael |
| author_facet | Junielson Soares da Silva Ana Cristina da Silva Pinto Samara Silva de Souza Francisco Célio Maia Chaves Sabrina da Fonseca Meireles Rosalina Pinheiro Pereira Rosemary Aparecida Roque João Marcelo de Castro e Sousa Míriam Silva Rafael |
| author_sort | Junielson Soares da Silva |
| collection | DOAJ |
| description | The study of substances of botanical origin is fundamental for the development of new effective alternatives for the control of <i>Aedes (Stegomyia) aegypti</i> (Culicidae), a vector of arboviruses in humans. In this study, the potential of two new dillapiole derivatives, propyl ether dillapiole and piperidyl dillapiole, was tested to determine their ability to deter oviposition and their larvicidal and residual effects against <i>Ae. aegypti</i> under simulated field conditions, as alternatives for the control of this mosquito. The ability of these substances to deter oviposition by pregnant <i>Ae. aegypti</i> females was assessed in the laboratory, and then the larvicide and residual effects of different concentrations were tested under simulated field conditions. The determination of the enzymatic activity in exposed larvae was carried out using sublethal concentrations. The LC<sub>50</sub> values of propyl ether dillapiole after 24 and 48 h were 24.60 µg/mL and 14.76 µg/mL, and those of piperidyl dillapiole were 31.58 µg/mL and 24.85 µg/mL, respectively. After 48 h of exposure to aged, treated water, the mortality of propyl ether dillapiole (100 µg/mL) and piperidyl dillapiole (200 µg/mL) fell to 81.7% and 75% on the second day, and to 73.3% and 66.7% on the fourth day, respectively. The concentrations of 100 µg/mL of propyl ether dillapiole and 200 µg/mL of piperidyl dillapiole caused oviposition rates of only 3.80% and 4.63% of the eggs of the females, respectively, compared to 22.01% in the negative control (water and DMSO at 2%). In the larvae exposed to propyl ether, piperidyl dillapiole, dillapiole, or the chemical insecticide temephos (positive control), inhibition of acetylcholinesterase (AChE) occurred. Propyl ether dillapiole and piperidyl dillapiole have potential for use as alternative forms of control of <i>Ae. aegypti</i>, with propyl ether dillapiole being the most promising molecule. Further studies are needed to understand the effects of these substances on this mosquito and on non-target organisms. |
| format | Article |
| id | doaj-art-05b45f400aac4f11ad0358766e493f51 |
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| publishDate | 2025-04-01 |
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| spelling | doaj-art-05b45f400aac4f11ad0358766e493f512025-08-20T02:25:04ZengMDPI AGToxics2305-63042025-04-0113428310.3390/toxics13040283Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae)Junielson Soares da Silva0Ana Cristina da Silva Pinto1Samara Silva de Souza2Francisco Célio Maia Chaves3Sabrina da Fonseca Meireles4Rosalina Pinheiro Pereira5Rosemary Aparecida Roque6João Marcelo de Castro e Sousa7Míriam Silva Rafael8Postgraduate Program in Genetics, Conservation and Evolutionary Biology, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69060-001, AM, BrazilLaboratory of Malaria and Dengue, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69067-375, AM, BrazilLaboratory of Ecophysiology and Molecular Evolution, National Institute of Amazonian Research, Manaus 69067-375, AM, BrazilLaboratory of Medicinal Plants and Phytochemistry, Embrapa Western Amazon, Manaus 69067-375, AM, BrazilPostgraduate Program in Genetics, Conservation and Evolutionary Biology, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69060-001, AM, BrazilLaboratory of Malaria and Dengue, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69067-375, AM, BrazilLaboratory of Malaria and Dengue, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69067-375, AM, BrazilGraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina 64049-550, PI, BrazilPostgraduate Program in Genetics, Conservation and Evolutionary Biology, Coordination of Society, Environment and Health, National Institute of Amazonian Research, Manaus 69060-001, AM, BrazilThe study of substances of botanical origin is fundamental for the development of new effective alternatives for the control of <i>Aedes (Stegomyia) aegypti</i> (Culicidae), a vector of arboviruses in humans. In this study, the potential of two new dillapiole derivatives, propyl ether dillapiole and piperidyl dillapiole, was tested to determine their ability to deter oviposition and their larvicidal and residual effects against <i>Ae. aegypti</i> under simulated field conditions, as alternatives for the control of this mosquito. The ability of these substances to deter oviposition by pregnant <i>Ae. aegypti</i> females was assessed in the laboratory, and then the larvicide and residual effects of different concentrations were tested under simulated field conditions. The determination of the enzymatic activity in exposed larvae was carried out using sublethal concentrations. The LC<sub>50</sub> values of propyl ether dillapiole after 24 and 48 h were 24.60 µg/mL and 14.76 µg/mL, and those of piperidyl dillapiole were 31.58 µg/mL and 24.85 µg/mL, respectively. After 48 h of exposure to aged, treated water, the mortality of propyl ether dillapiole (100 µg/mL) and piperidyl dillapiole (200 µg/mL) fell to 81.7% and 75% on the second day, and to 73.3% and 66.7% on the fourth day, respectively. The concentrations of 100 µg/mL of propyl ether dillapiole and 200 µg/mL of piperidyl dillapiole caused oviposition rates of only 3.80% and 4.63% of the eggs of the females, respectively, compared to 22.01% in the negative control (water and DMSO at 2%). In the larvae exposed to propyl ether, piperidyl dillapiole, dillapiole, or the chemical insecticide temephos (positive control), inhibition of acetylcholinesterase (AChE) occurred. Propyl ether dillapiole and piperidyl dillapiole have potential for use as alternative forms of control of <i>Ae. aegypti</i>, with propyl ether dillapiole being the most promising molecule. Further studies are needed to understand the effects of these substances on this mosquito and on non-target organisms.https://www.mdpi.com/2305-6304/13/4/283mosquitoinsecticidal<i>Piper aduncum</i>vector controlsemi-fieldmortality |
| spellingShingle | Junielson Soares da Silva Ana Cristina da Silva Pinto Samara Silva de Souza Francisco Célio Maia Chaves Sabrina da Fonseca Meireles Rosalina Pinheiro Pereira Rosemary Aparecida Roque João Marcelo de Castro e Sousa Míriam Silva Rafael Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) Toxics mosquito insecticidal <i>Piper aduncum</i> vector control semi-field mortality |
| title | Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) |
| title_full | Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) |
| title_fullStr | Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) |
| title_full_unstemmed | Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) |
| title_short | Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against <em>Aedes (Stegomyia) aegypti</em> (Diptera: Culicidae) |
| title_sort | oviposition deterrence and larvicidal activity of propyl ether dillapiole and piperidyl dillapiole against em aedes stegomyia aegypti em diptera culicidae |
| topic | mosquito insecticidal <i>Piper aduncum</i> vector control semi-field mortality |
| url | https://www.mdpi.com/2305-6304/13/4/283 |
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