The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27,...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/269541 |
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| Summary: | Atopic dermatitis (AD) is an inflammatory skin
disease in which pathogenesis chemokines are
partially involved. The aim of the paper was to
assess the serum level of CXCL-9, CXCL-10, CXCL-11,
CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and
IL-18 chosen in AD patients by ELISA assay. Forty
patients (mean age 11.4 years old) with AD and 50
healthy controls were enrolled into the study. The
patients and controls were divided into two age
categories: under 10 years old (Group 1 and Control 1)
and over 10 years old (Group 2 and Control 2).
Significantly lower serum concentration of CXCL-9,
CXCL-10, CCL-17, and IL-18 and higher concentration
of CXCL-12 and CCL-27 were found in Group 1 when
compared to Control 1. In Group 2 serum
concentration of CXCL-12, CCL-17, CCL-22 was higher
than in Control 2. The obtained results indicate the
imbalance in chemokine serum levels in AD what
suggests their role in the disease pathogenesis. |
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| ISSN: | 0962-9351 1466-1861 |