Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study
Abstract Accurate prediction of cardiovascular disease (CVD) mortality is essential for effective treatment decisions and risk management. Current models often lack comprehensive integration of key biomarkers, limiting their predictive power. This study aims to develop a predictive model for CVD-rel...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88790-y |
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| author | Zhen Wu Abdullahi Mohamud Hilowle Ying Zhou Changlin Zhao Shuo Yang |
| author_facet | Zhen Wu Abdullahi Mohamud Hilowle Ying Zhou Changlin Zhao Shuo Yang |
| author_sort | Zhen Wu |
| collection | DOAJ |
| description | Abstract Accurate prediction of cardiovascular disease (CVD) mortality is essential for effective treatment decisions and risk management. Current models often lack comprehensive integration of key biomarkers, limiting their predictive power. This study aims to develop a predictive model for CVD-related mortality using a machine learning-based feature selection algorithm and assess its performance compared to existing models. We analyzed data from a cohort of 4,882 adults recruited between 1999 and 2004, followed for up to 20 years. After applying the Boruta algorithm for feature selection, key biomarkers including NT-proBNP, cardiac troponins, and homocysteine were identified as significant predictors of CVD mortality. Predictive models were built using these biomarkers alongside demographic and clinical variables. Model performance was evaluated using the concordance index (C-index), sensitivity, specificity, and accuracy, with internal validation conducted through bootstrap sampling. Additionally, decision curve analysis (DCA) was performed to assess clinical benefit. The combined model, incorporating both biomarkers and demographic variables, demonstrated superior predictive performance with a C-index of 0.9205 (95% CI: 0.9129–0.9319), outperforming models with demographic variables alone (C-index: 0.9030 (95% CI: 0.8938–0.9147)) or biomarkers alone (C-index: 0.8659 (95% CI: 0.8519–0.8826)). Cox regression analysis further identified key predictors of CVD mortality, including elevated AST/ALT, TyG, BUN, and systolic blood pressure, with protective factors such as higher chloride and iron levels. Nomogram construction and DCA confirmed that the combined model provided substantial net benefit across various time points. The integration of cardiac biomarkers, lipid profiles, and inflammatory markers significantly improves the accuracy of predictive models for CVD-related mortality. This novel approach offers enhanced prognostication, with potential for further optimization through the inclusion of additional clinical and lifestyle data. |
| format | Article |
| id | doaj-art-05a8aadd6d1c471597db8a442db14e17 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-05a8aadd6d1c471597db8a442db14e172025-02-09T12:33:46ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-025-88790-yDelving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort studyZhen Wu0Abdullahi Mohamud Hilowle1Ying Zhou2Changlin Zhao3Shuo Yang4Cardiovascular Department, Third Affiliated Hospital of Sun Yat-sen UniversityCardiovascular Department, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of VIP Medical Service Center, The Third Affiliated Hospital of Sun Yat-sen UniversityCardiovascular Department, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Medical Statistics, School of Public Health, Sun Yat-sen UniversityAbstract Accurate prediction of cardiovascular disease (CVD) mortality is essential for effective treatment decisions and risk management. Current models often lack comprehensive integration of key biomarkers, limiting their predictive power. This study aims to develop a predictive model for CVD-related mortality using a machine learning-based feature selection algorithm and assess its performance compared to existing models. We analyzed data from a cohort of 4,882 adults recruited between 1999 and 2004, followed for up to 20 years. After applying the Boruta algorithm for feature selection, key biomarkers including NT-proBNP, cardiac troponins, and homocysteine were identified as significant predictors of CVD mortality. Predictive models were built using these biomarkers alongside demographic and clinical variables. Model performance was evaluated using the concordance index (C-index), sensitivity, specificity, and accuracy, with internal validation conducted through bootstrap sampling. Additionally, decision curve analysis (DCA) was performed to assess clinical benefit. The combined model, incorporating both biomarkers and demographic variables, demonstrated superior predictive performance with a C-index of 0.9205 (95% CI: 0.9129–0.9319), outperforming models with demographic variables alone (C-index: 0.9030 (95% CI: 0.8938–0.9147)) or biomarkers alone (C-index: 0.8659 (95% CI: 0.8519–0.8826)). Cox regression analysis further identified key predictors of CVD mortality, including elevated AST/ALT, TyG, BUN, and systolic blood pressure, with protective factors such as higher chloride and iron levels. Nomogram construction and DCA confirmed that the combined model provided substantial net benefit across various time points. The integration of cardiac biomarkers, lipid profiles, and inflammatory markers significantly improves the accuracy of predictive models for CVD-related mortality. This novel approach offers enhanced prognostication, with potential for further optimization through the inclusion of additional clinical and lifestyle data.https://doi.org/10.1038/s41598-025-88790-yCardiovascular diseaseMortality predictionMachine learningBiomarkers |
| spellingShingle | Zhen Wu Abdullahi Mohamud Hilowle Ying Zhou Changlin Zhao Shuo Yang Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study Scientific Reports Cardiovascular disease Mortality prediction Machine learning Biomarkers |
| title | Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study |
| title_full | Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study |
| title_fullStr | Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study |
| title_full_unstemmed | Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study |
| title_short | Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study |
| title_sort | delving into biomarkers and predictive modeling for cvd mortality a 20 year cohort study |
| topic | Cardiovascular disease Mortality prediction Machine learning Biomarkers |
| url | https://doi.org/10.1038/s41598-025-88790-y |
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