Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review
Epstein–Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare tumor that typically arises in the liver or spleen and is characterized by spindle-shaped cells within a dense lymphoplasmacytic background. We report a case of a 64-year-old woman with an incidental sp...
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| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1640099/full |
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| author | Yi Xiao Lanlan Li Xiumei Zhan Juner Xu Yewu Chen Qiuchan Zhao Yinghao Fu Xian Luo Huadi Chen Hao Xu |
| author_facet | Yi Xiao Lanlan Li Xiumei Zhan Juner Xu Yewu Chen Qiuchan Zhao Yinghao Fu Xian Luo Huadi Chen Hao Xu |
| author_sort | Yi Xiao |
| collection | DOAJ |
| description | Epstein–Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare tumor that typically arises in the liver or spleen and is characterized by spindle-shaped cells within a dense lymphoplasmacytic background. We report a case of a 64-year-old woman with an incidental splenic mass found during routine imaging. MRI showed a 4.8 cm lesion with progressive enhancement. The patient underwent laparoscopic partial splenectomy. Histopathological examination revealed features consistent with EBV+ IFDCS, including positivity for CD21, CD23, CD35, SMA, EMA, and EBER. EBV+ IFDCS often presents with nonspecific symptoms and imaging findings, making diagnosis challenging. Definitive diagnosis relies on histology, immunohistochemistry, and confirmation of EBV infection. Most cases follow an indolent clinical course and have a favorable prognosis after complete surgical resection, though rare aggressive cases have been reported. Understanding its clinicopathological and molecular features is essential for accurate diagnosis and management. |
| format | Article |
| id | doaj-art-05a81abff3ab4a10a41586cbc5559cf3 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-05a81abff3ab4a10a41586cbc5559cf32025-08-22T10:30:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.16400991640099Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature reviewYi Xiao0Lanlan Li1Xiumei Zhan2Juner Xu3Yewu Chen4Qiuchan Zhao5Yinghao Fu6Xian Luo7Huadi Chen8Hao Xu9Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaThe First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, ChinaThe First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, ChinaThe First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaEpstein–Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare tumor that typically arises in the liver or spleen and is characterized by spindle-shaped cells within a dense lymphoplasmacytic background. We report a case of a 64-year-old woman with an incidental splenic mass found during routine imaging. MRI showed a 4.8 cm lesion with progressive enhancement. The patient underwent laparoscopic partial splenectomy. Histopathological examination revealed features consistent with EBV+ IFDCS, including positivity for CD21, CD23, CD35, SMA, EMA, and EBER. EBV+ IFDCS often presents with nonspecific symptoms and imaging findings, making diagnosis challenging. Definitive diagnosis relies on histology, immunohistochemistry, and confirmation of EBV infection. Most cases follow an indolent clinical course and have a favorable prognosis after complete surgical resection, though rare aggressive cases have been reported. Understanding its clinicopathological and molecular features is essential for accurate diagnosis and management.https://www.frontiersin.org/articles/10.3389/fonc.2025.1640099/fullEpstein-Barr virus-positive inflammatory follicular dendritic cell sarcomaspleeninflammatory tumorlaparoscopic partial splenectomycase report |
| spellingShingle | Yi Xiao Lanlan Li Xiumei Zhan Juner Xu Yewu Chen Qiuchan Zhao Yinghao Fu Xian Luo Huadi Chen Hao Xu Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review Frontiers in Oncology Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma spleen inflammatory tumor laparoscopic partial splenectomy case report |
| title | Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review |
| title_full | Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review |
| title_fullStr | Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review |
| title_full_unstemmed | Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review |
| title_short | Spleen EBV-positive inflammatory follicular dendritic cell sarcoma: a case report and literature review |
| title_sort | spleen ebv positive inflammatory follicular dendritic cell sarcoma a case report and literature review |
| topic | Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma spleen inflammatory tumor laparoscopic partial splenectomy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1640099/full |
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