Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy
Abstract The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initia...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Cancer Immunology, Immunotherapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00262-024-03936-7 |
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| _version_ | 1832571630141833216 |
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| author | Shishengnan Song Chong Wang Yangchao Chen Xiaorong Zhou Yi Han Haijian Zhang |
| author_facet | Shishengnan Song Chong Wang Yangchao Chen Xiaorong Zhou Yi Han Haijian Zhang |
| author_sort | Shishengnan Song |
| collection | DOAJ |
| description | Abstract The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. Together they reflect the complexity of the changing dynamics of cancer immunity. Additionally, we have investigated the dynamic effects of tumor-infiltrating B lymphocytes in immunotherapy and their relationship to prognosis, providing new insights into potential treatment strategies for patients. |
| format | Article |
| id | doaj-art-05a1a8921be44fb296065bbac0827a1f |
| institution | Kabale University |
| issn | 1432-0851 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Cancer Immunology, Immunotherapy |
| spelling | doaj-art-05a1a8921be44fb296065bbac0827a1f2025-02-02T12:26:24ZengSpringerCancer Immunology, Immunotherapy1432-08512025-02-0174311510.1007/s00262-024-03936-7Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapyShishengnan Song0Chong Wang1Yangchao Chen2Xiaorong Zhou3Yi Han4Haijian Zhang5Research Center of Clinical Medicine, Affiliated Hospital of Nantong UniversityDepartment of Thoracic Surgery, Beijing Chest Hospital Affiliated to Capital Medical University (Beijing Tuberculosis and Thoracic Tumor Research Institute)School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong KongDepartment of Immunology, Medical School of Nantong UniversityDepartment of Thoracic Surgery, Beijing Chest Hospital Affiliated to Capital Medical University (Beijing Tuberculosis and Thoracic Tumor Research Institute)Research Center of Clinical Medicine, Affiliated Hospital of Nantong UniversityAbstract The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. Together they reflect the complexity of the changing dynamics of cancer immunity. Additionally, we have investigated the dynamic effects of tumor-infiltrating B lymphocytes in immunotherapy and their relationship to prognosis, providing new insights into potential treatment strategies for patients.https://doi.org/10.1007/s00262-024-03936-7Tumor-infiltrating B cellsTertiary lymphoid structuresGerminal centerTumor prognosisTumor-infiltrating lymphocyte |
| spellingShingle | Shishengnan Song Chong Wang Yangchao Chen Xiaorong Zhou Yi Han Haijian Zhang Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy Cancer Immunology, Immunotherapy Tumor-infiltrating B cells Tertiary lymphoid structures Germinal center Tumor prognosis Tumor-infiltrating lymphocyte |
| title | Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy |
| title_full | Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy |
| title_fullStr | Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy |
| title_full_unstemmed | Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy |
| title_short | Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy |
| title_sort | dynamic roles of tumor infiltrating b lymphocytes in cancer immunotherapy |
| topic | Tumor-infiltrating B cells Tertiary lymphoid structures Germinal center Tumor prognosis Tumor-infiltrating lymphocyte |
| url | https://doi.org/10.1007/s00262-024-03936-7 |
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