Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis

Abstract Background & Aim We aimed in this study to investigate the relationship between Androgen Deprivation Therapy (ADT) use and the risk of heart failure in patients with prostate cancer. In this research, the negative or positive effects of ADT in the development of cardiovascular diseases...

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Main Authors: Amir Alinejad Khorram, Reyhaneh Pourasgharian, Ali Samadi Shams, Shahin Toufani, Mehrsa Mostafaei, Reza Khademi, Reza Daghayeghi, Maryam Valifard, Mehregan shahrokhi, Sina Seyedipour, Niloofar Deravi, Mahdyieh Naziri, Mahta Malek, Faizan Bashir
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Cardiovascular Disorders
Subjects:
Androgen deprivation therapy
Prostate cancer
Cardiovascular disease
heart failure
Online Access:https://doi.org/10.1186/s12872-024-04421-w
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Summary:Abstract Background & Aim We aimed in this study to investigate the relationship between Androgen Deprivation Therapy (ADT) use and the risk of heart failure in patients with prostate cancer. In this research, the negative or positive effects of ADT in the development of cardiovascular diseases or its exacerbation in people with prostate cancer have been investigated. Materials and methods For this research, we reviewed articles from PubMed, Scopus, and Google Scholar databases until February 2024. We extracted and screened titles, abstracts, and full texts of related articles. The quality of studies was assessed and extracted and analyzed data. Result A total of 9 studies comprising 189,045 patients were included in the meta-analysis, examining the association between androgen deprivation therapy (ADT) and heart failure. The overall pooled hazard ratio (HR) was 1.299 (95% CI: 1.003–1.595), indicating a significantly increased risk of heart failure with ADT. Subgroup analyses revealed that the risk was stronger in Asian populations (pooled HR = 1.545, 95% CI: 1.180–1.910) compared to North American populations (pooled HR = 0.779, 95% CI: 0.421–1.138). Conclusions ADT has a significant relationship with cardiovascular disease. According to the analysis, ADT has increased the risk of heart failure in people with prostate cancer by 30%.
ISSN:1471-2261

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