Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population
BackgroundDiabetes is a leading cause of death, affecting nearly half a billion adults worldwide. With projections indicating a significant increase in prevalence, understanding the genetic factors that contribute to diabetes, particularly type 2, is crucial.MethodsThis study investigated the associ...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Clinical Diabetes and Healthcare |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1494128/full |
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| author | Darya Zakirova Alisher Abdullaev Dilbar Dalimova Elina Aguryanova Fazliddin Khonboev Nilyufar Khushvakova Nodira Alikhanova Feruza Takhirova |
| author_facet | Darya Zakirova Alisher Abdullaev Dilbar Dalimova Elina Aguryanova Fazliddin Khonboev Nilyufar Khushvakova Nodira Alikhanova Feruza Takhirova |
| author_sort | Darya Zakirova |
| collection | DOAJ |
| description | BackgroundDiabetes is a leading cause of death, affecting nearly half a billion adults worldwide. With projections indicating a significant increase in prevalence, understanding the genetic factors that contribute to diabetes, particularly type 2, is crucial.MethodsThis study investigated the association of specific polymorphisms with type 2 diabetes (T2D) in the Uzbek population. A total of 165 individuals, including 125 patients with T2D and 40 controls, were genotyped for variants located in the DOCK7, ABCG8, UBE2E2, SYN2, HNF1A, and IGF2BP2 genes using real-time polymerase chain reaction.ResultsThe analysis revealed significant associations between these polymorphisms and T2D under various genetic models. The distribution of the genotype frequencies was consistent with the Hardy–Weinberg equilibrium.ConclusionThe findings of this study underscore the importance of ethnic and geographical diversity in genetic studies and contribute to the understanding of T2D in the Uzbek population. Further research is needed to explore the clinical implications of these genetic associations. |
| format | Article |
| id | doaj-art-05999f3ee03a49f98ee3727a4f263f4a |
| institution | DOAJ |
| issn | 2673-6616 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Clinical Diabetes and Healthcare |
| spelling | doaj-art-05999f3ee03a49f98ee3727a4f263f4a2025-08-20T03:04:45ZengFrontiers Media S.A.Frontiers in Clinical Diabetes and Healthcare2673-66162025-02-01610.3389/fcdhc.2025.14941281494128Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek populationDarya Zakirova0Alisher Abdullaev1Dilbar Dalimova2Elina Aguryanova3Fazliddin Khonboev4Nilyufar Khushvakova5Nodira Alikhanova6Feruza Takhirova7Biotechnology Department, Center for Advanced Technologies, Tashkent, UzbekistanBiotechnology Department, Center for Advanced Technologies, Tashkent, UzbekistanBiotechnology Department, Center for Advanced Technologies, Tashkent, UzbekistanBiotechnology Department, Center for Advanced Technologies, Tashkent, UzbekistanBiotechnology Department, Center for Advanced Technologies, Tashkent, UzbekistanDepartment of Endocrinology, Samarkand State Medical University, Samarkand, UzbekistanDiabetology Department of the Republican Specialized Scientific-Practical Medical Center of Endocrinology Named after Academician Y.Kh.Turakulov, Tashkent, UzbekistanDiabetology Department of the Republican Specialized Scientific-Practical Medical Center of Endocrinology Named after Academician Y.Kh.Turakulov, Tashkent, UzbekistanBackgroundDiabetes is a leading cause of death, affecting nearly half a billion adults worldwide. With projections indicating a significant increase in prevalence, understanding the genetic factors that contribute to diabetes, particularly type 2, is crucial.MethodsThis study investigated the association of specific polymorphisms with type 2 diabetes (T2D) in the Uzbek population. A total of 165 individuals, including 125 patients with T2D and 40 controls, were genotyped for variants located in the DOCK7, ABCG8, UBE2E2, SYN2, HNF1A, and IGF2BP2 genes using real-time polymerase chain reaction.ResultsThe analysis revealed significant associations between these polymorphisms and T2D under various genetic models. The distribution of the genotype frequencies was consistent with the Hardy–Weinberg equilibrium.ConclusionThe findings of this study underscore the importance of ethnic and geographical diversity in genetic studies and contribute to the understanding of T2D in the Uzbek population. Further research is needed to explore the clinical implications of these genetic associations.https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1494128/fulltype 2 diabetesUzbek populationrs4299376rs6780569rs7616006rs12749263 |
| spellingShingle | Darya Zakirova Alisher Abdullaev Dilbar Dalimova Elina Aguryanova Fazliddin Khonboev Nilyufar Khushvakova Nodira Alikhanova Feruza Takhirova Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population Frontiers in Clinical Diabetes and Healthcare type 2 diabetes Uzbek population rs4299376 rs6780569 rs7616006 rs12749263 |
| title | Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population |
| title_full | Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population |
| title_fullStr | Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population |
| title_full_unstemmed | Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population |
| title_short | Polymorphic variants in DOCK7, ABCG8, UBE2E2, and SYN2 genes associated with type 2 diabetes in the Uzbek population |
| title_sort | polymorphic variants in dock7 abcg8 ube2e2 and syn2 genes associated with type 2 diabetes in the uzbek population |
| topic | type 2 diabetes Uzbek population rs4299376 rs6780569 rs7616006 rs12749263 |
| url | https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1494128/full |
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