Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center
Abstract Background Clinical characteristics and outcomes of carbapenem-resistant Enterobacterales (CRE) infection and colonization have rarely been reported in patients with severe burns, who are prone to severe bacterial infections. This study aimed to evaluate clinical characteristics and outcome...
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BMC
2025-01-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-025-01514-9 |
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| author | Myongjin Kim Kibum Jeon Dohern Kym Jinsun Jung Yu Jin Jang Seung Beom Han |
| author_facet | Myongjin Kim Kibum Jeon Dohern Kym Jinsun Jung Yu Jin Jang Seung Beom Han |
| author_sort | Myongjin Kim |
| collection | DOAJ |
| description | Abstract Background Clinical characteristics and outcomes of carbapenem-resistant Enterobacterales (CRE) infection and colonization have rarely been reported in patients with severe burns, who are prone to severe bacterial infections. This study aimed to evaluate clinical characteristics and outcomes of CRE infection and colonization in patients with severe burns. Methods The characteristics of 106 episodes of CRE acquisition (infection or colonization) in 98 patients with severe burns were evaluated by a retrospective medical record review. The duration of rectal CRE colonization and its associated factors were determined in the survived patients. Results Five (4.7%) of the CRE acquisitions were identified on admission, and the remaining 101 (95.3%) were identified at a median of 11 days (range 2–75 days) after admission. Klebsiella pneumoniae represented 73.6% of the isolated CRE strains, and carbapenemase-producing CRE (CP-CRE) were identified in 70.8% of the isolates. Mortality was associated with an abbreviated burn severity index (ABSI) score ≥ 10 (p < 0.001) and previous carbapenem-resistant bacterial acquisition (protective, p = 0.010). For the 58 episodes of CRE acquisition in the survived patients, eradication of rectal CRE colonization was identified in 39 (67.2%) at a median of 64 days (range 10–434 days) after acquisition. CP-CRE strains were associated with prolonged rectal CRE colonization (p < 0.001). Conclusions The characteristics of CRE infection and colonization in patients with severe burns were similar to those in general critical patients. Enhanced infection prevention and control measures should be considered for patients with severe burns of an ABSI score ≥ 10 and those with CP-CRE. |
| format | Article |
| id | doaj-art-0597d3f59630401f8f906c9ba7177460 |
| institution | Kabale University |
| issn | 2047-2994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj-art-0597d3f59630401f8f906c9ba71774602025-02-02T12:43:07ZengBMCAntimicrobial Resistance and Infection Control2047-29942025-01-0114111010.1186/s13756-025-01514-9Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn centerMyongjin Kim0Kibum Jeon1Dohern Kym2Jinsun Jung3Yu Jin Jang4Seung Beom Han5Department of Surgery and Critical care, Burn Center, Hallym University Hangang Sacred Heart HospitalInfection Control and Prevention Unit, Hallym University Hangang Sacred Heart HospitalDepartment of Surgery and Critical care, Burn Center, Hallym University Hangang Sacred Heart HospitalInfection Control and Prevention Unit, Hallym University Hangang Sacred Heart HospitalInfection Control and Prevention Unit, Hallym University Hangang Sacred Heart HospitalDepartment of Pediatrics, College of Medicine, The Catholic University of KoreaAbstract Background Clinical characteristics and outcomes of carbapenem-resistant Enterobacterales (CRE) infection and colonization have rarely been reported in patients with severe burns, who are prone to severe bacterial infections. This study aimed to evaluate clinical characteristics and outcomes of CRE infection and colonization in patients with severe burns. Methods The characteristics of 106 episodes of CRE acquisition (infection or colonization) in 98 patients with severe burns were evaluated by a retrospective medical record review. The duration of rectal CRE colonization and its associated factors were determined in the survived patients. Results Five (4.7%) of the CRE acquisitions were identified on admission, and the remaining 101 (95.3%) were identified at a median of 11 days (range 2–75 days) after admission. Klebsiella pneumoniae represented 73.6% of the isolated CRE strains, and carbapenemase-producing CRE (CP-CRE) were identified in 70.8% of the isolates. Mortality was associated with an abbreviated burn severity index (ABSI) score ≥ 10 (p < 0.001) and previous carbapenem-resistant bacterial acquisition (protective, p = 0.010). For the 58 episodes of CRE acquisition in the survived patients, eradication of rectal CRE colonization was identified in 39 (67.2%) at a median of 64 days (range 10–434 days) after acquisition. CP-CRE strains were associated with prolonged rectal CRE colonization (p < 0.001). Conclusions The characteristics of CRE infection and colonization in patients with severe burns were similar to those in general critical patients. Enhanced infection prevention and control measures should be considered for patients with severe burns of an ABSI score ≥ 10 and those with CP-CRE.https://doi.org/10.1186/s13756-025-01514-9Carbapenem-resistant EnterobacteriaceaeCarbapenemaseInfectionsBurnsKorea |
| spellingShingle | Myongjin Kim Kibum Jeon Dohern Kym Jinsun Jung Yu Jin Jang Seung Beom Han Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center Antimicrobial Resistance and Infection Control Carbapenem-resistant Enterobacteriaceae Carbapenemase Infections Burns Korea |
| title | Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center |
| title_full | Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center |
| title_fullStr | Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center |
| title_full_unstemmed | Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center |
| title_short | Carbapenem-resistant Enterobacterales infection and colonization in patients with severe burns: a retrospective cohort study in a single burn center |
| title_sort | carbapenem resistant enterobacterales infection and colonization in patients with severe burns a retrospective cohort study in a single burn center |
| topic | Carbapenem-resistant Enterobacteriaceae Carbapenemase Infections Burns Korea |
| url | https://doi.org/10.1186/s13756-025-01514-9 |
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