Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR
Background Intraoperative hypothermia is a significant life-threatening emergency during surgery in patients with Hirschsprung’s disease (HSCR). The aim of this study is to explore the risk factors and predictors of intraoperative hypothermia in HSCR patients.Methods This cohort comprised 85 patient...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2540019 |
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| author | Xiaohui Huang Mobai Ren Junrong Pan Ene Huang Yanhong Li Donghao Guo Junjie Wang |
| author_facet | Xiaohui Huang Mobai Ren Junrong Pan Ene Huang Yanhong Li Donghao Guo Junjie Wang |
| author_sort | Xiaohui Huang |
| collection | DOAJ |
| description | Background Intraoperative hypothermia is a significant life-threatening emergency during surgery in patients with Hirschsprung’s disease (HSCR). The aim of this study is to explore the risk factors and predictors of intraoperative hypothermia in HSCR patients.Methods This cohort comprised 85 patients with HSCR who underwent surgery at Quanzhou Children’s Hospital and the patients were divided into the intraoperative non-hypothermia group and the intraoperative hypothermia group. The study compared the characteristics of two groups and used univariate and multiple logistic regression analyses to assess the potential risk factors for intraoperative hypothermia. Models were adjusted for covariates, and interaction terms were evaluated for albumin (ALB) and intraoperative hypothermia. Subgroup analysis included stratification by sex and age. ROC analysis was applied to determine the optimal threshold for ALB.Results In this retrospective study, 71 patients had intraoperative non-hypothermia and 14 patients had intraoperative hypothermia (83.5% versus 16.5%). Comparing the clinical characteristics between two groups, baseline core temperature, ALB and alkaline phosphatase (p < .001, p = .001 and p = .036, respectively) showed significant differences. Univariate logistic regression showed that baseline core temperature (OR = 0.001, 95%CI = 0.000–0.024, p < .001), ALB (OR = 0.820, 95%CI = 0.679–0.972, p = .028) and gamma-glutamyl transferase (OR = 1.017, 95%CI = 1.001–1.035, p = .043) had significant associations with intraoperative hypothermia. Multiple logistic regression showed that both ALB (OR = 0.782, 95%CI = 0.611–0.965, p = .031) and baseline core temperature (OR = 0.001, 95%CI = 0.000–0.019, p < .001) were negatively associated with intraoperative hypothermia. The relationship between ALB and intraoperative hypothermia remained significant after adjusting for covariates. ROC analysis identified 41.45 g/L as the optimal threshold of ALB for predicting intraoperative hypothermia, with a sensitivity of 85.71% and a specificity of 64.79%.Conclusion ALB is an independent risk factor for intraoperative hypothermia in HSCR patients. Further investments are required to explore its mechanisms. |
| format | Article |
| id | doaj-art-059739df4d3d403d9e7ffdcbd4da93b7 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-059739df4d3d403d9e7ffdcbd4da93b72025-08-20T03:58:49ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2540019Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCRXiaohui Huang0Mobai Ren1Junrong Pan2Ene Huang3Yanhong Li4Donghao Guo5Junjie Wang6Department of Operating Room, Quanzhou Women’s and Children’s Hospital, Quanzhou, ChinaSchool of Clinical Medicine, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Operating Room, Quanzhou Women’s and Children’s Hospital, Quanzhou, ChinaDepartment of Operating Room, Quanzhou Women’s and Children’s Hospital, Quanzhou, ChinaDepartment of Pediatric Endocrinology, Quanzhou Women’s and Children’s Hospital, Quanzhou, ChinaDepartment of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Pediatric Endocrinology, Quanzhou Women’s and Children’s Hospital, Quanzhou, ChinaBackground Intraoperative hypothermia is a significant life-threatening emergency during surgery in patients with Hirschsprung’s disease (HSCR). The aim of this study is to explore the risk factors and predictors of intraoperative hypothermia in HSCR patients.Methods This cohort comprised 85 patients with HSCR who underwent surgery at Quanzhou Children’s Hospital and the patients were divided into the intraoperative non-hypothermia group and the intraoperative hypothermia group. The study compared the characteristics of two groups and used univariate and multiple logistic regression analyses to assess the potential risk factors for intraoperative hypothermia. Models were adjusted for covariates, and interaction terms were evaluated for albumin (ALB) and intraoperative hypothermia. Subgroup analysis included stratification by sex and age. ROC analysis was applied to determine the optimal threshold for ALB.Results In this retrospective study, 71 patients had intraoperative non-hypothermia and 14 patients had intraoperative hypothermia (83.5% versus 16.5%). Comparing the clinical characteristics between two groups, baseline core temperature, ALB and alkaline phosphatase (p < .001, p = .001 and p = .036, respectively) showed significant differences. Univariate logistic regression showed that baseline core temperature (OR = 0.001, 95%CI = 0.000–0.024, p < .001), ALB (OR = 0.820, 95%CI = 0.679–0.972, p = .028) and gamma-glutamyl transferase (OR = 1.017, 95%CI = 1.001–1.035, p = .043) had significant associations with intraoperative hypothermia. Multiple logistic regression showed that both ALB (OR = 0.782, 95%CI = 0.611–0.965, p = .031) and baseline core temperature (OR = 0.001, 95%CI = 0.000–0.019, p < .001) were negatively associated with intraoperative hypothermia. The relationship between ALB and intraoperative hypothermia remained significant after adjusting for covariates. ROC analysis identified 41.45 g/L as the optimal threshold of ALB for predicting intraoperative hypothermia, with a sensitivity of 85.71% and a specificity of 64.79%.Conclusion ALB is an independent risk factor for intraoperative hypothermia in HSCR patients. Further investments are required to explore its mechanisms.https://www.tandfonline.com/doi/10.1080/07853890.2025.2540019Intraoperative hypothermiaHirschsprung’s diseasealbumin |
| spellingShingle | Xiaohui Huang Mobai Ren Junrong Pan Ene Huang Yanhong Li Donghao Guo Junjie Wang Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR Annals of Medicine Intraoperative hypothermia Hirschsprung’s disease albumin |
| title | Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR |
| title_full | Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR |
| title_fullStr | Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR |
| title_full_unstemmed | Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR |
| title_short | Albumin: a novel biomarker for predicting intraoperative hypothermia in HSCR |
| title_sort | albumin a novel biomarker for predicting intraoperative hypothermia in hscr |
| topic | Intraoperative hypothermia Hirschsprung’s disease albumin |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2540019 |
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