Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine
Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patie...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/3295786 |
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| author | Adham Abu Taha Ahmad Yaseen Sa’d Suleiman Omar Abu Zenah Hammam Ali Rania Abu Seir Khaled Younis |
| author_facet | Adham Abu Taha Ahmad Yaseen Sa’d Suleiman Omar Abu Zenah Hammam Ali Rania Abu Seir Khaled Younis |
| author_sort | Adham Abu Taha |
| collection | DOAJ |
| description | Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were examined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen patients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years (range: 12–24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D (33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age, sex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization. |
| format | Article |
| id | doaj-art-058cbc61bba44189a1f450d51da7b289 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-058cbc61bba44189a1f450d51da7b2892025-02-03T05:51:10ZengWileyAdvances in Hematology1687-91041687-91122019-01-01201910.1155/2019/32957863295786Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from PalestineAdham Abu Taha0Ahmad Yaseen1Sa’d Suleiman2Omar Abu Zenah3Hammam Ali4Rania Abu Seir5Khaled Younis6College of Medicine and Health Sciences, An-Najah National University, Nablus, State of PalestineCollege of Medicine and Health Sciences, An-Najah National University, Nablus, State of PalestineCollege of Medicine and Health Sciences, An-Najah National University, Nablus, State of PalestineCollege of Medicine and Health Sciences, An-Najah National University, Nablus, State of PalestineDepartment of Medical Lab Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of PalestineDepartment of Medical Lab Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of PalestineDepartment of Medical Lab Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of PalestineBackground. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were examined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen patients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years (range: 12–24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D (33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age, sex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization.http://dx.doi.org/10.1155/2019/3295786 |
| spellingShingle | Adham Abu Taha Ahmad Yaseen Sa’d Suleiman Omar Abu Zenah Hammam Ali Rania Abu Seir Khaled Younis Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine Advances in Hematology |
| title | Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine |
| title_full | Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine |
| title_fullStr | Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine |
| title_full_unstemmed | Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine |
| title_short | Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine |
| title_sort | study of frequency and characteristics of red blood cell alloimmunization in thalassemic patients multicenter study from palestine |
| url | http://dx.doi.org/10.1155/2019/3295786 |
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