Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Abstract Background The potential role of Klebsiella pneumoniae (K.pn) in hypertension development has been emphasized, although the specific mechanisms have not been well understood. Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions by deliverin...

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Main Authors: Xinxin Li, Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, Wen Zhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan, Huina Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Klebsiella pneumoniae (K.pn)
Bacterial extracellular vesicles (BEVs)
Endothelial dysfunction
Endothelial senescence
SIRT1
Online Access:https://doi.org/10.1186/s12964-024-02002-0
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