Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers
Abstract PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER‐2 (n...
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Springer Nature
2021-07-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202114398 |
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| author | Rik Ossenkoppele Juhan Reimand Ruben Smith Antoine Leuzy Olof Strandberg Sebastian Palmqvist Erik Stomrud Henrik Zetterberg the Alzheimer's Disease Neuroimaging Initiative Philip Scheltens Jeffrey L Dage Femke Bouwman Kaj Blennow Niklas Mattsson‐Carlgren Shorena Janelidze Oskar Hansson |
| author_facet | Rik Ossenkoppele Juhan Reimand Ruben Smith Antoine Leuzy Olof Strandberg Sebastian Palmqvist Erik Stomrud Henrik Zetterberg the Alzheimer's Disease Neuroimaging Initiative Philip Scheltens Jeffrey L Dage Femke Bouwman Kaj Blennow Niklas Mattsson‐Carlgren Shorena Janelidze Oskar Hansson |
| author_sort | Rik Ossenkoppele |
| collection | DOAJ |
| description | Abstract PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER‐2 (n = 400) and ADNI (n = 371). All had tau‐PET ([18F]RO948 in BioFINDER‐2, [18F]flortaucipir in ADNI) and CSF p‐tau181 biomarkers available. Plasma p‐tau181 and plasma/CSF p‐tau217 were available in BioFINDER‐2 only. Concordance between PET, CSF and plasma tau biomarkers ranged between 66 and 95%. Across the whole group, ridge regression models showed that increased CSF and plasma p‐tau181 and p‐tau217 levels were independently of tau PET associated with higher age, and APOEɛ4‐carriership and Aβ‐positivity, while increased tau‐PET signal in the temporal cortex was associated with worse cognitive performance and reduced cortical thickness. We conclude that biofluid and neuroimaging markers of tau pathology convey partly independent information, with CSF and plasma p‐tau181 and p‐tau217 levels being more tightly linked with early markers of AD (especially Aβ‐pathology), while tau‐PET shows the strongest associations with cognitive and neurodegenerative markers of disease progression. |
| format | Article |
| id | doaj-art-057a0cbad93e4950bcab674977a33f6d |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-057a0cbad93e4950bcab674977a33f6d2025-08-20T03:43:29ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-07-0113811510.15252/emmm.202114398Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkersRik Ossenkoppele0Juhan Reimand1Ruben Smith2Antoine Leuzy3Olof Strandberg4Sebastian Palmqvist5Erik Stomrud6Henrik Zetterberg7the Alzheimer's Disease Neuroimaging InitiativePhilip Scheltens8Jeffrey L Dage9Femke Bouwman10Kaj Blennow11Niklas Mattsson‐Carlgren12Shorena Janelidze13Oskar Hansson14Clinical Memory Research Unit, Lund UniversityAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityClinical Neurochemistry Laboratory, Sahlgrenska University HospitalAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCEli Lilly and CompanyAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMCClinical Neurochemistry Laboratory, Sahlgrenska University HospitalClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityAbstract PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER‐2 (n = 400) and ADNI (n = 371). All had tau‐PET ([18F]RO948 in BioFINDER‐2, [18F]flortaucipir in ADNI) and CSF p‐tau181 biomarkers available. Plasma p‐tau181 and plasma/CSF p‐tau217 were available in BioFINDER‐2 only. Concordance between PET, CSF and plasma tau biomarkers ranged between 66 and 95%. Across the whole group, ridge regression models showed that increased CSF and plasma p‐tau181 and p‐tau217 levels were independently of tau PET associated with higher age, and APOEɛ4‐carriership and Aβ‐positivity, while increased tau‐PET signal in the temporal cortex was associated with worse cognitive performance and reduced cortical thickness. We conclude that biofluid and neuroimaging markers of tau pathology convey partly independent information, with CSF and plasma p‐tau181 and p‐tau217 levels being more tightly linked with early markers of AD (especially Aβ‐pathology), while tau‐PET shows the strongest associations with cognitive and neurodegenerative markers of disease progression.https://doi.org/10.15252/emmm.202114398Alzheimer's diseaseCSFPETplasmatau |
| spellingShingle | Rik Ossenkoppele Juhan Reimand Ruben Smith Antoine Leuzy Olof Strandberg Sebastian Palmqvist Erik Stomrud Henrik Zetterberg the Alzheimer's Disease Neuroimaging Initiative Philip Scheltens Jeffrey L Dage Femke Bouwman Kaj Blennow Niklas Mattsson‐Carlgren Shorena Janelidze Oskar Hansson Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers EMBO Molecular Medicine Alzheimer's disease CSF PET plasma tau |
| title | Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers |
| title_full | Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers |
| title_fullStr | Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers |
| title_full_unstemmed | Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers |
| title_short | Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers |
| title_sort | tau pet correlates with different alzheimer s disease related features compared to csf and plasma p tau biomarkers |
| topic | Alzheimer's disease CSF PET plasma tau |
| url | https://doi.org/10.15252/emmm.202114398 |
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