Targeting Spermine Oxidase to Mitigate Traumatic Brain Injury Pathology in the Aging Brain

Targeting Spermine Oxidase to Mitigate Traumatic Brain Injury Pathology in the Aging Brain

Traumatic brain injury (TBI) in the elderly is frequently associated with worsened neurological outcomes and prolonged recovery, yet the age-specific molecular mechanisms driving this vulnerability remain poorly understood. Aging is characterized by increased oxidative stress and chronic neuro-infla...

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Bibliographic Details
Main Authors: Jui-Ming Sun, Jing-Shiun Jan, Ting-Lin Yen, Yu-Hao Chen, Ruei-Dun Teng, Chih-Hao Yang, Cheng-Ta Hsieh
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
spermine oxidase
traumatic brain injury
aging brain
oxidative stress
neuro-inflammation
neuronal cell death
Online Access:https://www.mdpi.com/2076-3921/14/6/709
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