Nucleosome organization of mouse embryos during pre-implantation development

Nucleosome organization of mouse embryos during pre-implantation development

Abstract Sexual reproduction begins with sperm–oocyte fusion to form a zygote, where chromatin undergoes dramatic reorganization to establish totipotency. Although nucleosomes- the basic units of eukaryotic chromatin and key epigenetic regulators- are extensively remodeled during early embryogenesis...

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Main Authors: Jitao Zeng, Xiaojuan Tu, Siming Qu, Xichan Chen, Ying Wang, Xiaona Liu, Enchuan Kang, Yi Tian, Qianming Xiang, Binbin Lai, Weiwu Gao, Bing Ni, Wei He
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
scMNase-seq
Embryos
Nucleosome position
Chromatin organization
H3K4me3
Online Access:https://doi.org/10.1038/s41598-025-05642-5
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