Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica
Synergetic and antagonistic medicinal activities of crude and fractionated essential oil from the seed of Monodora myristica were investigated. The crude essential oil was extracted by steam distillation and then subjected to column chromatography; three fractions (N1, N2, and N3) were obtained. To...
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Can Tho University Publisher
2023-11-01
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| Series: | CTU Journal of Innovation and Sustainable Development |
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| Online Access: | https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/590 |
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| author | Shola H. Awojide Boluwatife Akinlade Kehinde Adenike Oyewole Abayomi G. Adeyemo Emmanuel O. Adeniyi Olumide E. Fadunmade Adebanjo J. Anifowose |
| author_facet | Shola H. Awojide Boluwatife Akinlade Kehinde Adenike Oyewole Abayomi G. Adeyemo Emmanuel O. Adeniyi Olumide E. Fadunmade Adebanjo J. Anifowose |
| author_sort | Shola H. Awojide |
| collection | DOAJ |
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Synergetic and antagonistic medicinal activities of crude and fractionated essential oil from the seed of Monodora myristica were investigated. The crude essential oil was extracted by steam distillation and then subjected to column chromatography; three fractions (N1, N2, and N3) were obtained. To identify the components, gas chromatography and mass spectrometry (GC-MS) investigation was utilized. The phytochemical parameters were determined by standard analytical methods. 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) were used to evaluate the antioxidative capacity. and, the anti-diabetic activity was performed using α-amylase and α-glucosidase assay. The Agar diffusion method was used to determine the antibacterial activities. The GC-MS analysis indicated p-cymene (21.12%) as the major component of the crude essential oil. The antioxidant activity using DPPH varied from 614 to 704 µg/mL, while the ABTS activity ranged between 281-342 µg/mL. The α-amylase assay showed fraction N1 with IC50 value of 3.21 µg/mL, while for α-glucosidase assay, fraction N2 with IC50 2.15 µg/mL recorded the least value. The minimum inhibitory concentration values for the crude extract and all the fractions against the strains of bacteria ranged from 6 to 12.5 mg/mL Both crude extract and fractionated essential oil showed antioxidant, anti-diabetic and antibacterial activities.
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| format | Article |
| id | doaj-art-056f8589ed3c4ab2b1a0247076164a2a |
| institution | DOAJ |
| issn | 2588-1418 2815-6412 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Can Tho University Publisher |
| record_format | Article |
| series | CTU Journal of Innovation and Sustainable Development |
| spelling | doaj-art-056f8589ed3c4ab2b1a0247076164a2a2025-08-20T03:12:36ZengCan Tho University PublisherCTU Journal of Innovation and Sustainable Development2588-14182815-64122023-11-0115310.22144/ctujoisd.2023.046Synergistic and antagonistic medicinal activities of essential oil of Monodora myristicaShola H. AwojideBoluwatife AkinladeKehinde Adenike Oyewole0Abayomi G. AdeyemoEmmanuel O. AdeniyiOlumide E. FadunmadeAdebanjo J. Anifowosea:1:{s:5:"en_US";s:21:"Osun State University";} Synergetic and antagonistic medicinal activities of crude and fractionated essential oil from the seed of Monodora myristica were investigated. The crude essential oil was extracted by steam distillation and then subjected to column chromatography; three fractions (N1, N2, and N3) were obtained. To identify the components, gas chromatography and mass spectrometry (GC-MS) investigation was utilized. The phytochemical parameters were determined by standard analytical methods. 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) were used to evaluate the antioxidative capacity. and, the anti-diabetic activity was performed using α-amylase and α-glucosidase assay. The Agar diffusion method was used to determine the antibacterial activities. The GC-MS analysis indicated p-cymene (21.12%) as the major component of the crude essential oil. The antioxidant activity using DPPH varied from 614 to 704 µg/mL, while the ABTS activity ranged between 281-342 µg/mL. The α-amylase assay showed fraction N1 with IC50 value of 3.21 µg/mL, while for α-glucosidase assay, fraction N2 with IC50 2.15 µg/mL recorded the least value. The minimum inhibitory concentration values for the crude extract and all the fractions against the strains of bacteria ranged from 6 to 12.5 mg/mL Both crude extract and fractionated essential oil showed antioxidant, anti-diabetic and antibacterial activities. https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/590Antagonistic, essential oil, medicinal, Monodora myristica, synergic |
| spellingShingle | Shola H. Awojide Boluwatife Akinlade Kehinde Adenike Oyewole Abayomi G. Adeyemo Emmanuel O. Adeniyi Olumide E. Fadunmade Adebanjo J. Anifowose Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica CTU Journal of Innovation and Sustainable Development Antagonistic, essential oil, medicinal, Monodora myristica, synergic |
| title | Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica |
| title_full | Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica |
| title_fullStr | Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica |
| title_full_unstemmed | Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica |
| title_short | Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica |
| title_sort | synergistic and antagonistic medicinal activities of essential oil of monodora myristica |
| topic | Antagonistic, essential oil, medicinal, Monodora myristica, synergic |
| url | https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/590 |
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