Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria
The rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development of innovative therapeutic strategies to overcome these challenges. Copper-based nanomaterials have emerged as promising agents due to their intrinsic antibacterial properties,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/4/708 |
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| author | Yujie Zhai Zhuxiao Liang Xijun Liu Weiqing Zhang |
| author_facet | Yujie Zhai Zhuxiao Liang Xijun Liu Weiqing Zhang |
| author_sort | Yujie Zhai |
| collection | DOAJ |
| description | The rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development of innovative therapeutic strategies to overcome these challenges. Copper-based nanomaterials have emerged as promising agents due to their intrinsic antibacterial properties, cost-effectiveness, and adaptability for multifunctional therapeutic approaches. These materials exhibit exceptional potential in advanced antibacterial therapies, including chemodynamic therapy (CDT), photothermal therapy (PTT), and photodynamic therapy (PDT). Their unique physicochemical properties, such as controlled ion release, reactive oxygen species (ROS) generation, and tunable catalytic activity, enable them to target MDR bacteria effectively while minimizing off-target effects. This paper systematically reviews the mechanisms through which Cu-based nanomaterials enhance antibacterial efficiency and emphasizes their specific performance in the antibacterial field. Key factors influencing their antibacterial properties—such as electronic interactions, photothermal characteristics, size effects, ligand effects, single-atom doping, and geometric configurations—are analyzed in depth. By uncovering the potential of copper-based nanomaterials, this work aims to inspire innovative approaches that improve patient outcomes, reduce the burden of bacterial infections, and enhance global public health initiatives. |
| format | Article |
| id | doaj-art-05677e1fb06e494085fc38869b79ab5c |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-05677e1fb06e494085fc38869b79ab5c2025-08-20T02:28:38ZengMDPI AGMicroorganisms2076-26072025-03-0113470810.3390/microorganisms13040708Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant BacteriaYujie Zhai0Zhuxiao Liang1Xijun Liu2Weiqing Zhang3State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, ChinaDepartment of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaState Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, ChinaDepartment of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaThe rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development of innovative therapeutic strategies to overcome these challenges. Copper-based nanomaterials have emerged as promising agents due to their intrinsic antibacterial properties, cost-effectiveness, and adaptability for multifunctional therapeutic approaches. These materials exhibit exceptional potential in advanced antibacterial therapies, including chemodynamic therapy (CDT), photothermal therapy (PTT), and photodynamic therapy (PDT). Their unique physicochemical properties, such as controlled ion release, reactive oxygen species (ROS) generation, and tunable catalytic activity, enable them to target MDR bacteria effectively while minimizing off-target effects. This paper systematically reviews the mechanisms through which Cu-based nanomaterials enhance antibacterial efficiency and emphasizes their specific performance in the antibacterial field. Key factors influencing their antibacterial properties—such as electronic interactions, photothermal characteristics, size effects, ligand effects, single-atom doping, and geometric configurations—are analyzed in depth. By uncovering the potential of copper-based nanomaterials, this work aims to inspire innovative approaches that improve patient outcomes, reduce the burden of bacterial infections, and enhance global public health initiatives.https://www.mdpi.com/2076-2607/13/4/708drug-resistant bacteriaantibacterial mechanismCu-based nanomaterials |
| spellingShingle | Yujie Zhai Zhuxiao Liang Xijun Liu Weiqing Zhang Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria Microorganisms drug-resistant bacteria antibacterial mechanism Cu-based nanomaterials |
| title | Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria |
| title_full | Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria |
| title_fullStr | Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria |
| title_full_unstemmed | Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria |
| title_short | Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria |
| title_sort | employing copper based nanomaterials to combat multi drug resistant bacteria |
| topic | drug-resistant bacteria antibacterial mechanism Cu-based nanomaterials |
| url | https://www.mdpi.com/2076-2607/13/4/708 |
| work_keys_str_mv | AT yujiezhai employingcopperbasednanomaterialstocombatmultidrugresistantbacteria AT zhuxiaoliang employingcopperbasednanomaterialstocombatmultidrugresistantbacteria AT xijunliu employingcopperbasednanomaterialstocombatmultidrugresistantbacteria AT weiqingzhang employingcopperbasednanomaterialstocombatmultidrugresistantbacteria |