Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases
Cytology is an exam frequently used as a diagnostic technique to evaluate animal oral lesions. However, the retrospective studies published comparing cytology and histology in oral pathology are scarce. This study aimed to determining the association between diagnostic cytology and histopathology in...
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2025-01-01
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| author | Paula Brilhante-Simões Leonor Delgado Ângela Martins Augusto Silva Luís Monteiro Ricardo Marcos Justina Prada |
| author_facet | Paula Brilhante-Simões Leonor Delgado Ângela Martins Augusto Silva Luís Monteiro Ricardo Marcos Justina Prada |
| author_sort | Paula Brilhante-Simões |
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| description | Cytology is an exam frequently used as a diagnostic technique to evaluate animal oral lesions. However, the retrospective studies published comparing cytology and histology in oral pathology are scarce. This study aimed to determining the association between diagnostic cytology and histopathology in neoplastic and non-neoplastic samples from oral cavity lesions of dogs and cats. Cytological and histological samples (<i>n</i> = 103) of oral lesions from 70 dogs and 33 cats collected over 12 years were compared in terms of agreement, considering the histopathology as the gold standard. Of 103 specimens, 78 were classified as neoplastic, and 25 were non-neoplastic. The sensitivity, specificity, and accuracy of cytology in neoplastic and non-neoplastic lesions were 84.6%, 96.0%, and 87.4%. Of the overall 103 cases, 75.7% (<i>n</i> = 78) were neoplastic and revealed an agreement that was complete in 64.1% (<i>n</i> = 50) and partial in 17.9% (<i>n</i> = 14) samples, and the remaining 17.9% (<i>n</i> = 14) revealed disagreement; regarding the non-neoplastic diagnoses (24.3%, <i>n</i> = 25) the agreement was complete in 68.0% (<i>n</i> = 17), partial for 20.0% (<i>n</i> = 5) samples, and the remaining 12.0% (<i>n</i> = 3) revealed disagreement. A statistical association between neoplastic cases and agreement was obtained (<i>p</i> < 0.0001). The high agreement verified between the cytological and histopathological diagnoses emphasizes the role of cytology as the first approach method to an oral lesion in dogs and cats. |
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| spelling | doaj-art-055eeeed008b4490b5da19c6140f16b72025-08-20T02:17:24ZengMDPI AGVeterinary Sciences2306-73812025-01-011227510.3390/vetsci12020075Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 CasesPaula Brilhante-Simões0Leonor Delgado1Ângela Martins2Augusto Silva3Luís Monteiro4Ricardo Marcos5Justina Prada6INNO Veterinary Laboratories, R. Cândido de Sousa 15, 4710-300 Braga, PortugalINNO Veterinary Laboratories, R. Cândido de Sousa 15, 4710-300 Braga, PortugalDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, PortugalINNO Veterinary Laboratories, R. Cândido de Sousa 15, 4710-300 Braga, PortugalGIPOC—Comparative Oral Pathology Research Group, University Institute of Health Sciences—Advanced Polytechnic and University Cooperative (IUCS-CESPU), 4585-116 Gandra, PortugalCytology and Hematology Diagnostic Services, Laboratory of Histology and Embryology, Department of Microscopy, ICBAS-School of Medicine and Biomedical Sciences, University of Porto (U.Porto), Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, PortugalCytology is an exam frequently used as a diagnostic technique to evaluate animal oral lesions. However, the retrospective studies published comparing cytology and histology in oral pathology are scarce. This study aimed to determining the association between diagnostic cytology and histopathology in neoplastic and non-neoplastic samples from oral cavity lesions of dogs and cats. Cytological and histological samples (<i>n</i> = 103) of oral lesions from 70 dogs and 33 cats collected over 12 years were compared in terms of agreement, considering the histopathology as the gold standard. Of 103 specimens, 78 were classified as neoplastic, and 25 were non-neoplastic. The sensitivity, specificity, and accuracy of cytology in neoplastic and non-neoplastic lesions were 84.6%, 96.0%, and 87.4%. Of the overall 103 cases, 75.7% (<i>n</i> = 78) were neoplastic and revealed an agreement that was complete in 64.1% (<i>n</i> = 50) and partial in 17.9% (<i>n</i> = 14) samples, and the remaining 17.9% (<i>n</i> = 14) revealed disagreement; regarding the non-neoplastic diagnoses (24.3%, <i>n</i> = 25) the agreement was complete in 68.0% (<i>n</i> = 17), partial for 20.0% (<i>n</i> = 5) samples, and the remaining 12.0% (<i>n</i> = 3) revealed disagreement. A statistical association between neoplastic cases and agreement was obtained (<i>p</i> < 0.0001). The high agreement verified between the cytological and histopathological diagnoses emphasizes the role of cytology as the first approach method to an oral lesion in dogs and cats.https://www.mdpi.com/2306-7381/12/2/75cytologyoral lesionsneoplasiacaninefeline |
| spellingShingle | Paula Brilhante-Simões Leonor Delgado Ângela Martins Augusto Silva Luís Monteiro Ricardo Marcos Justina Prada Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases Veterinary Sciences cytology oral lesions neoplasia canine feline |
| title | Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases |
| title_full | Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases |
| title_fullStr | Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases |
| title_full_unstemmed | Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases |
| title_short | Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases |
| title_sort | association between cytological and histopathological diagnoses of neoplastic and non neoplastic lesions in oral cavity from dogs and cats an observational retrospective study of 103 cases |
| topic | cytology oral lesions neoplasia canine feline |
| url | https://www.mdpi.com/2306-7381/12/2/75 |
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