Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations

Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations

IntroductionUnderstanding leukemia-associated immunophenotypes (LAIP) could assist in the design of therapies to ameliorate patient benefits in acute myeloid leukemia (AML). In our study, focusing on single-cell heterogeneity in therapeutic resistance, flow cytometric immunophenotyping of the periph...

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Main Authors: Nikolett Gémes, Benedek Rónaszéki, Szabolcs Modok, Zita Borbényi, Imre Földesi, Éva Trucza, Blanka Godza, Zsuzsanna László, Balázs Csernus, László Krenács, Enikő Bagdi, Enikő Szabó, László G. Puskás, Valeria Bertagnolo, Gábor J. Szebeni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
single-cell immunophenotyping
leukemia-associated immunophenotype
acute myeloid leukemia
drug resistance
minimal residual disease
luminex MAGPIX
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563386/full
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