A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan
Beiji nairovirus (BJNV), in the family Nairoviridae, the order Bunyavirales, was recently reported as a causative agent of an emerging tick-borne zoonotic infection in China. This study investigated the prevalence of BJNV in ticks in Japan. Screening of over 2,000 ticks from multiple regions reveale...
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Elsevier
2024-11-01
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| Series: | Ticks and Tick-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1877959X24000736 |
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| author | Mai Kishimoto Yukari Itakura Koshiro Tabata Rika Komagome Hiroki Yamaguchi Kohei Ogasawara Ryo Nakao Yongjin Qiu Kozue Sato Hiroki Kawabata Masahiro Kajihara Naota Monma Junji Seto Asako Shigeno Masayuki Horie Michihito Sasaki William W. Hall Hirofumi Sawa Yasuko Orba Keita Matsuno |
| author_facet | Mai Kishimoto Yukari Itakura Koshiro Tabata Rika Komagome Hiroki Yamaguchi Kohei Ogasawara Ryo Nakao Yongjin Qiu Kozue Sato Hiroki Kawabata Masahiro Kajihara Naota Monma Junji Seto Asako Shigeno Masayuki Horie Michihito Sasaki William W. Hall Hirofumi Sawa Yasuko Orba Keita Matsuno |
| author_sort | Mai Kishimoto |
| collection | DOAJ |
| description | Beiji nairovirus (BJNV), in the family Nairoviridae, the order Bunyavirales, was recently reported as a causative agent of an emerging tick-borne zoonotic infection in China. This study investigated the prevalence of BJNV in ticks in Japan. Screening of over 2,000 ticks from multiple regions revealed a widespread distribution of BJNV and BJNV-related viruses in Japan, particularly in the northern island, and in other high altitude areas with exclusive occurrence of Ixodes ticks. Phylogenetic analysis identified three distinct groups of nairoviruses in ticks in Japan: BJNV, Yichun nairovirus (YCNV) and a newly identified Mikuni nairovirus (MKNV). BJNV and YCNV variants identified in ticks in Japan exhibited high nucleotide sequence identities to those in China and Russia with evidence of non-monophyletic evolution among BJNVs, suggesting multiple cross-border transmission events of BJNV between the Eurasian continent and Japan. Whole genome sequencing of BJNV and MKNV revealed a unique GA-rich region in the S segment, the significance of which remains to be determined. In conclusion, the present study has shown a wide distribution and diversity of BJNV-related nairoviruses in Ixodes ticks in Japan and has identified unique genomic structures. The findings demonstrate the significance of BJNV as well as related viruses in Japan and highlight the necessity of monitoring emerging nairovirus infections and their potential risks to public health. |
| format | Article |
| id | doaj-art-054d8fc4587f4b729e2fc305ba0dbafe |
| institution | DOAJ |
| issn | 1877-9603 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ticks and Tick-Borne Diseases |
| spelling | doaj-art-054d8fc4587f4b729e2fc305ba0dbafe2025-08-20T02:39:31ZengElsevierTicks and Tick-Borne Diseases1877-96032024-11-0115610238010.1016/j.ttbdis.2024.102380A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in JapanMai Kishimoto0Yukari Itakura1Koshiro Tabata2Rika Komagome3Hiroki Yamaguchi4Kohei Ogasawara5Ryo Nakao6Yongjin Qiu7Kozue Sato8Hiroki Kawabata9Masahiro Kajihara10Naota Monma11Junji Seto12Asako Shigeno13Masayuki Horie14Michihito Sasaki15William W. Hall16Hirofumi Sawa17Yasuko Orba18Keita Matsuno19Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Laboratory of Veterinary Microbiology, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, JapanDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, JapanDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, JapanCenter for Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, JapanCenter for Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, JapanLaboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, JapanLaboratory of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, JapanLaboratory of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, JapanDepartment of Bacteriology-I, National Institute of Infectious Diseases, Tokyo, JapanDepartment of Bacteriology-I, National Institute of Infectious Diseases, Tokyo, JapanDivision of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Sapporo, JapanDepartment of Infection Control, Fukushima Medical University, Fukushima, JapanYamagata Prefectural Institute of Public Health, Yamagata, JapanDivision of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, Sapporo, JapanLaboratory of Veterinary Microbiology, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, Japan; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, JapanDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, JapanInstitute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, Japan; National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin, Ireland; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Global Virus Network, Baltimore, Maryland, USADivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, Japan; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Global Virus Network, Baltimore, Maryland, USA; One Health Research Center, Hokkaido University, Sapporo, JapanDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, Japan; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; One Health Research Center, Hokkaido University, Sapporo, Japan; Corresponding author at: Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, N20, W10, Kita-ku, Sapporo 001-0020, Japan.Institute for Vaccine Research and Development (HU-IVReD) , Hokkaido University, Sapporo, Japan; Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan; One Health Research Center, Hokkaido University, Sapporo, Japan; Corresponding author at: Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, N20, W10, Kita-ku, Sapporo 001-0020, Japan.Beiji nairovirus (BJNV), in the family Nairoviridae, the order Bunyavirales, was recently reported as a causative agent of an emerging tick-borne zoonotic infection in China. This study investigated the prevalence of BJNV in ticks in Japan. Screening of over 2,000 ticks from multiple regions revealed a widespread distribution of BJNV and BJNV-related viruses in Japan, particularly in the northern island, and in other high altitude areas with exclusive occurrence of Ixodes ticks. Phylogenetic analysis identified three distinct groups of nairoviruses in ticks in Japan: BJNV, Yichun nairovirus (YCNV) and a newly identified Mikuni nairovirus (MKNV). BJNV and YCNV variants identified in ticks in Japan exhibited high nucleotide sequence identities to those in China and Russia with evidence of non-monophyletic evolution among BJNVs, suggesting multiple cross-border transmission events of BJNV between the Eurasian continent and Japan. Whole genome sequencing of BJNV and MKNV revealed a unique GA-rich region in the S segment, the significance of which remains to be determined. In conclusion, the present study has shown a wide distribution and diversity of BJNV-related nairoviruses in Ixodes ticks in Japan and has identified unique genomic structures. The findings demonstrate the significance of BJNV as well as related viruses in Japan and highlight the necessity of monitoring emerging nairovirus infections and their potential risks to public health.http://www.sciencedirect.com/science/article/pii/S1877959X24000736NairovirusTick-borne diseasesArbovirusGenetic diversity |
| spellingShingle | Mai Kishimoto Yukari Itakura Koshiro Tabata Rika Komagome Hiroki Yamaguchi Kohei Ogasawara Ryo Nakao Yongjin Qiu Kozue Sato Hiroki Kawabata Masahiro Kajihara Naota Monma Junji Seto Asako Shigeno Masayuki Horie Michihito Sasaki William W. Hall Hirofumi Sawa Yasuko Orba Keita Matsuno A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan Ticks and Tick-Borne Diseases Nairovirus Tick-borne diseases Arbovirus Genetic diversity |
| title | A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan |
| title_full | A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan |
| title_fullStr | A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan |
| title_full_unstemmed | A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan |
| title_short | A wide distribution of Beiji nairoviruses and related viruses in Ixodes ticks in Japan |
| title_sort | wide distribution of beiji nairoviruses and related viruses in ixodes ticks in japan |
| topic | Nairovirus Tick-borne diseases Arbovirus Genetic diversity |
| url | http://www.sciencedirect.com/science/article/pii/S1877959X24000736 |
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