Sex differences in metabolic dysfunction-associated steatotic liver disease: a narrative review
Understanding the effects of sex and sex differences on liver health and disease is crucial for individualized healthcare and informed decision-making for patients with liver disease. The impact of sex on liver disease varies according to i...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ewha Womans University College of Medicine
2024-04-01
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| Series: | The Ewha Medical Journal |
| Subjects: | |
| Online Access: | http://www.e-emj.org/archive/view_article?pid=emj-47-2-17 |
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| Summary: | Understanding the effects of sex and sex differences on liver health and disease
is crucial for individualized healthcare and informed decision-making for
patients with liver disease. The impact of sex on liver disease varies according
to its etiology. Women have a lower prevalence of metabolic
dysfunction-associated steatotic liver disease (MASLD) than men. However,
postmenopausal women face a higher risk of advanced liver fibrosis due to
hormonal influences. Sex differences affect the pathogenesis of MASLD, which
involves a complex process involving several factors such as hormones, obesity,
and the gut microbiome. Furthermore, sex-related differences in the development
of MASLDrelated hepatocellular carcinoma have been observed. The sex-specific
characteristics of MASLD necessitate an individualized management approach based
on scientific evidence. However, research in this area has been lacking. This
article reviews the current understanding of sex differences in MASLD. |
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| ISSN: | 2234-2591 |