Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review
Non-neoplastic portal vein thrombosis (PVT) is an increasingly recognized complication of liver cirrhosis. It is often diagnosed fortuitously and can be either partial or complete. The clinical significance of PVT is not obvious except in some situations such as when patients are on the waiting list...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/672986 |
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| _version_ | 1832555966104600576 |
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| author | Geneviève Huard Marc Bilodeau |
| author_facet | Geneviève Huard Marc Bilodeau |
| author_sort | Geneviève Huard |
| collection | DOAJ |
| description | Non-neoplastic portal vein thrombosis (PVT) is an increasingly recognized complication of liver cirrhosis. It is often diagnosed fortuitously and can be either partial or complete. The clinical significance of PVT is not obvious except in some situations such as when patients are on the waiting list for liver transplantation. The only known therapy is anticoagulation which has been shown to permit the disappearance of thrombosis and to prevent further extension. Anticoagulation is a challenging therapy in individuals with liver cirrhosis because of the well-recognized coagulation abnormalities observed in that setting and because of the increased risk of bleeding, especially from gastrointestinal tract caused by portal hypertension. We herein review the current knowledge on that topic in order to highlight the advantages and disadvantages of the currently proposed therapeutic attitudes in face of the diagnosis of PVT in individuals with cirrhosis. |
| format | Article |
| id | doaj-art-054989c885134e15b3fe691e0368a51d |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-054989c885134e15b3fe691e0368a51d2025-02-03T05:46:36ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/672986672986Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic ReviewGeneviève Huard0Marc Bilodeau1Liver Unit, Hôpital Saint-Luc, Centre Hospitalier de l’Université de Montréal, Montréal, QC, H2X 3J4, CanadaLiver Unit, Hôpital Saint-Luc, Centre Hospitalier de l’Université de Montréal, Montréal, QC, H2X 3J4, CanadaNon-neoplastic portal vein thrombosis (PVT) is an increasingly recognized complication of liver cirrhosis. It is often diagnosed fortuitously and can be either partial or complete. The clinical significance of PVT is not obvious except in some situations such as when patients are on the waiting list for liver transplantation. The only known therapy is anticoagulation which has been shown to permit the disappearance of thrombosis and to prevent further extension. Anticoagulation is a challenging therapy in individuals with liver cirrhosis because of the well-recognized coagulation abnormalities observed in that setting and because of the increased risk of bleeding, especially from gastrointestinal tract caused by portal hypertension. We herein review the current knowledge on that topic in order to highlight the advantages and disadvantages of the currently proposed therapeutic attitudes in face of the diagnosis of PVT in individuals with cirrhosis.http://dx.doi.org/10.1155/2012/672986 |
| spellingShingle | Geneviève Huard Marc Bilodeau Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review International Journal of Hepatology |
| title | Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review |
| title_full | Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review |
| title_fullStr | Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review |
| title_full_unstemmed | Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review |
| title_short | Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review |
| title_sort | management of anticoagulation for portal vein thrombosis in individuals with cirrhosis a systematic review |
| url | http://dx.doi.org/10.1155/2012/672986 |
| work_keys_str_mv | AT genevievehuard managementofanticoagulationforportalveinthrombosisinindividualswithcirrhosisasystematicreview AT marcbilodeau managementofanticoagulationforportalveinthrombosisinindividualswithcirrhosisasystematicreview |