Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants
Cell polarity establishment, maintenance, and alteration are central to the developmental and response programs of nearly all organisms and are often implicated in abnormalities ranging from patterning defects to cancer. By residing at the distinct plasma membrane domains polar cargoes mark the iden...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/981658 |
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| author | Pankaj Dhonukshe |
| author_facet | Pankaj Dhonukshe |
| author_sort | Pankaj Dhonukshe |
| collection | DOAJ |
| description | Cell polarity establishment, maintenance, and alteration are central to the developmental and response programs of nearly all organisms and are often implicated in abnormalities ranging from patterning defects to cancer. By residing at the distinct plasma membrane domains polar cargoes mark the identities of those domains, and execute localized functions. Polar cargoes are recruited to the specialized membrane domains by directional secretion and/or directional endocytic recycling. In plants, auxin efflux carrier PIN proteins display polar localizations in various cell types and play major roles in directional cell-to-cell transport of signaling molecule auxin that is vital for plant patterning and response programs. Recent advanced microscopy studies applied to single cells in intact plants reveal subcellular PIN dynamics. They uncover the PIN polarity generation mechanism and identified important roles of AGC kinases for polar PIN localization. AGC kinase family members PINOID, WAG1, and WAG2, belonging to the AGC-3 subclass predominantly influence the polar localization of PINs. The emerging mechanism for AGC-3 kinases action suggests that kinases phosphorylate PINs mainly at the plasma membrane after initial symmetric PIN secretion for eventual PIN internalization and PIN sorting into distinct ARF-GEF-regulated polar recycling pathways. Thus phosphorylation status directs PIN translocation to different cell sides. Based on these findings a mechanistic framework evolves that suggests existence of cell side-specific recycling pathways in plants and implicates AGC3 kinases for differential PIN recruitment among them for eventual PIN polarity establishment, maintenance, and alteration. |
| format | Article |
| id | doaj-art-05468a286a1d49c0b0a532b1a2286887 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-05468a286a1d49c0b0a532b1a22868872025-02-03T05:57:49ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/981658981658Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in PlantsPankaj Dhonukshe0Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The NetherlandsCell polarity establishment, maintenance, and alteration are central to the developmental and response programs of nearly all organisms and are often implicated in abnormalities ranging from patterning defects to cancer. By residing at the distinct plasma membrane domains polar cargoes mark the identities of those domains, and execute localized functions. Polar cargoes are recruited to the specialized membrane domains by directional secretion and/or directional endocytic recycling. In plants, auxin efflux carrier PIN proteins display polar localizations in various cell types and play major roles in directional cell-to-cell transport of signaling molecule auxin that is vital for plant patterning and response programs. Recent advanced microscopy studies applied to single cells in intact plants reveal subcellular PIN dynamics. They uncover the PIN polarity generation mechanism and identified important roles of AGC kinases for polar PIN localization. AGC kinase family members PINOID, WAG1, and WAG2, belonging to the AGC-3 subclass predominantly influence the polar localization of PINs. The emerging mechanism for AGC-3 kinases action suggests that kinases phosphorylate PINs mainly at the plasma membrane after initial symmetric PIN secretion for eventual PIN internalization and PIN sorting into distinct ARF-GEF-regulated polar recycling pathways. Thus phosphorylation status directs PIN translocation to different cell sides. Based on these findings a mechanistic framework evolves that suggests existence of cell side-specific recycling pathways in plants and implicates AGC3 kinases for differential PIN recruitment among them for eventual PIN polarity establishment, maintenance, and alteration.http://dx.doi.org/10.1100/2012/981658 |
| spellingShingle | Pankaj Dhonukshe Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants The Scientific World Journal |
| title | Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants |
| title_full | Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants |
| title_fullStr | Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants |
| title_full_unstemmed | Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants |
| title_short | Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants |
| title_sort | mechanistic framework for establishment maintenance and alteration of cell polarity in plants |
| url | http://dx.doi.org/10.1100/2012/981658 |
| work_keys_str_mv | AT pankajdhonukshe mechanisticframeworkforestablishmentmaintenanceandalterationofcellpolarityinplants |