PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA
We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder. The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan. Flow cytometry analysis of perip...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2010-09-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/182 |
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| author | Mark E. Johns Lynn C. Moscinski Lubomir Sokol |
| author_facet | Mark E. Johns Lynn C. Moscinski Lubomir Sokol |
| author_sort | Mark E. Johns |
| collection | DOAJ |
| description | We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder. The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan. Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant immunophenotype. Additionally, a TCR beta gene was found to be clonally rearranged in both peripheral blood and bone marrow supporting a clonal origin of atypical T cells. However, no such clonal population of T-cells could be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes. After discontinuing the patient’s phenytoin, his lymphadenopathy has nearly completely resolved and circulation clonal T cell population disappeared with 12 months of follow-up. |
| format | Article |
| id | doaj-art-0544ac366e4b4fabbcc1fa9eaaef621f |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2010-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-0544ac366e4b4fabbcc1fa9eaaef621f2025-08-20T01:47:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-09-0122e2010028e201002810.4084/mjhid.2010.02875PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMAMark E. JohnsLynn C. MoscinskiLubomir SokolWe report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder. The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan. Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant immunophenotype. Additionally, a TCR beta gene was found to be clonally rearranged in both peripheral blood and bone marrow supporting a clonal origin of atypical T cells. However, no such clonal population of T-cells could be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes. After discontinuing the patient’s phenytoin, his lymphadenopathy has nearly completely resolved and circulation clonal T cell population disappeared with 12 months of follow-up.http://www.mjhid.org/index.php/mjhid/article/view/182Lymphoma, psedolymphoma, Phenitoine |
| spellingShingle | Mark E. Johns Lynn C. Moscinski Lubomir Sokol PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA Mediterranean Journal of Hematology and Infectious Diseases Lymphoma, psedolymphoma, Phenitoine |
| title | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_full | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_fullStr | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_full_unstemmed | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_short | PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA |
| title_sort | phenytoin associated lymphoadenopathy mimicking a peripheral t cell lymphoma |
| topic | Lymphoma, psedolymphoma, Phenitoine |
| url | http://www.mjhid.org/index.php/mjhid/article/view/182 |
| work_keys_str_mv | AT markejohns phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma AT lynncmoscinski phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma AT lubomirsokol phenytoinassociatedlymphoadenopathymimickingaperipheraltcelllymphoma |