Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives
Two new Ag(I) complexes with coumaric carboxylic acid derivatives have been synthesized. Structural studies of these noncrystalline complexes have been performed using a methodology that combines laboratory and synchrotron techniques, supported by density functional theory calculations. The arrangem...
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2024-10-01
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| author | Anna Wolska Aleksandra Drzewiecka-Antonik Cristina Aparecida Barboza Marta Struga Joanna Stefanska Pawel Rejmak Marcin Klepka |
| author_facet | Anna Wolska Aleksandra Drzewiecka-Antonik Cristina Aparecida Barboza Marta Struga Joanna Stefanska Pawel Rejmak Marcin Klepka |
| author_sort | Anna Wolska |
| collection | DOAJ |
| description | Two new Ag(I) complexes with coumaric carboxylic acid derivatives have been synthesized. Structural studies of these noncrystalline complexes have been performed using a methodology that combines laboratory and synchrotron techniques, supported by density functional theory calculations. The arrangement of ligands around the Ag(I) cation has been refined using infrared, extended X-ray absorption fine structure, and X-ray absorption near edge structure spectroscopies. Different coordination modes of carboxylate ligands are observed for the studied compounds. Carboxylate bridges are characteristic for the Ag(I) complex with 4-oxo-4<i>H</i>-1-benzopyran-2-carboxylic acid (<b>1</b>), while a bidentate chelating motif was found for the complex with 2-oxo-2<i>H</i>-1-benzopyran-3-carboxylic acid (<b>2</b>). Additionally, the carbonyl oxygen atom of the coumarin ring coordinates to the silver cation in complex <b>2</b>, while it is inactive in complex <b>1</b>. Antimicrobial evaluation has been performed for both compounds. The complexes show activity against selected bacteria as well as <i>Candida</i> yeast. This activity is slightly lower for bacteria and the same or higher for <i>Candida</i> in relation to the reference substances: ciprofloxacin or fluconazole. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-10-01 |
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| series | Molecules |
| spelling | doaj-art-0537bdb78f2444898d29502fd865138c2024-11-08T14:37:59ZengMDPI AGMolecules1420-30492024-10-012921499310.3390/molecules29214993Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid DerivativesAnna Wolska0Aleksandra Drzewiecka-Antonik1Cristina Aparecida Barboza2Marta Struga3Joanna Stefanska4Pawel Rejmak5Marcin Klepka6Institute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, PL-02097 Warsaw, PolandDepartment of Pharmaceutical Microbiology and Bioanalysis, Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, PL-02097 Warsaw, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandTwo new Ag(I) complexes with coumaric carboxylic acid derivatives have been synthesized. Structural studies of these noncrystalline complexes have been performed using a methodology that combines laboratory and synchrotron techniques, supported by density functional theory calculations. The arrangement of ligands around the Ag(I) cation has been refined using infrared, extended X-ray absorption fine structure, and X-ray absorption near edge structure spectroscopies. Different coordination modes of carboxylate ligands are observed for the studied compounds. Carboxylate bridges are characteristic for the Ag(I) complex with 4-oxo-4<i>H</i>-1-benzopyran-2-carboxylic acid (<b>1</b>), while a bidentate chelating motif was found for the complex with 2-oxo-2<i>H</i>-1-benzopyran-3-carboxylic acid (<b>2</b>). Additionally, the carbonyl oxygen atom of the coumarin ring coordinates to the silver cation in complex <b>2</b>, while it is inactive in complex <b>1</b>. Antimicrobial evaluation has been performed for both compounds. The complexes show activity against selected bacteria as well as <i>Candida</i> yeast. This activity is slightly lower for bacteria and the same or higher for <i>Candida</i> in relation to the reference substances: ciprofloxacin or fluconazole.https://www.mdpi.com/1420-3049/29/21/4993metal-organic ligand complexesXAFSATR-IR spectroscopystructural analysisantimicrobial activity |
| spellingShingle | Anna Wolska Aleksandra Drzewiecka-Antonik Cristina Aparecida Barboza Marta Struga Joanna Stefanska Pawel Rejmak Marcin Klepka Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives Molecules metal-organic ligand complexes XAFS ATR-IR spectroscopy structural analysis antimicrobial activity |
| title | Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives |
| title_full | Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives |
| title_fullStr | Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives |
| title_full_unstemmed | Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives |
| title_short | Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives |
| title_sort | structural and biological studies of bioactive silver i complexes with coumarin acid derivatives |
| topic | metal-organic ligand complexes XAFS ATR-IR spectroscopy structural analysis antimicrobial activity |
| url | https://www.mdpi.com/1420-3049/29/21/4993 |
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