Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico
In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to investigate the occurrence of Leishmania infe...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/8392005 |
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| author | Erika I. Sosa-Bibiano Luis A. Sánchez -Martínez Karina B. López-Ávila Juan B. Chablé-Santos Jimmy R. Torres-Castro Edith A. Fernández-Figueroa Claudia Rangel-Escareño Elsy N. Loría-Cervera |
| author_facet | Erika I. Sosa-Bibiano Luis A. Sánchez -Martínez Karina B. López-Ávila Juan B. Chablé-Santos Jimmy R. Torres-Castro Edith A. Fernández-Figueroa Claudia Rangel-Escareño Elsy N. Loría-Cervera |
| author_sort | Erika I. Sosa-Bibiano |
| collection | DOAJ |
| description | In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to investigate the occurrence of Leishmania infection in wild rodents. From November 2019 to February 2020, rodents were caught from three sites located in the municipality of Tinum, Yucatan. For each specimen, clinical signs suggestive of Leishmania infection were recorded. Samples from the tail, liver, and spleen were taken for the identification of Leishmania DNA by PCR. Twenty rodents belonging to two species were caught including Heteromys gaumeri (55%, 11/20) and Ototylomys phyllotis (45%, 9/20). Fifty-five percent of the animals presented white spots on the tail, 15% had splenomegaly, and 5% had hepatomegaly. Fifty-five percent (11/20) of the animals were found infected by Leishmania. Heteromys gaumeri was caught in all trapping sites and was the most infected species (63.6%, 7/11). The percentage of infection for O. phyllotis was 44.4% (4/9). Leishmania (Leishmania) mexicana was identified as the infecting species in two H. gaumeri. This study provides, for the first time, evidence of Leishmania infection in wild rodents from the Yucatan state. Heteromys gaumeri and O. phyllotis may be involved in the transmission cycle of L. mexicana in this emergent focus; however, further longitudinal studies are needed to confirm their role as primary reservoirs. |
| format | Article |
| id | doaj-art-052f060f4d9b457ca5754d3fb4191dbd |
| institution | OA Journals |
| issn | 1687-9694 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-052f060f4d9b457ca5754d3fb4191dbd2025-08-20T02:02:57ZengWileyJournal of Tropical Medicine1687-96942022-01-01202210.1155/2022/8392005Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, MexicoErika I. Sosa-Bibiano0Luis A. Sánchez -Martínez1Karina B. López-Ávila2Juan B. Chablé-Santos3Jimmy R. Torres-Castro4Edith A. Fernández-Figueroa5Claudia Rangel-Escareño6Elsy N. Loría-Cervera7Laboratorio de InmunologíaLaboratorio de InmunologíaLaboratorio de InmunologíaDepartamento de ZoologíaDirección de Prevención y Protección de la Salud de los Servicios de Salud del Estado de YucatánComputational Genomics and Integrative BiologyComputational Genomics and Integrative BiologyLaboratorio de InmunologíaIn 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to investigate the occurrence of Leishmania infection in wild rodents. From November 2019 to February 2020, rodents were caught from three sites located in the municipality of Tinum, Yucatan. For each specimen, clinical signs suggestive of Leishmania infection were recorded. Samples from the tail, liver, and spleen were taken for the identification of Leishmania DNA by PCR. Twenty rodents belonging to two species were caught including Heteromys gaumeri (55%, 11/20) and Ototylomys phyllotis (45%, 9/20). Fifty-five percent of the animals presented white spots on the tail, 15% had splenomegaly, and 5% had hepatomegaly. Fifty-five percent (11/20) of the animals were found infected by Leishmania. Heteromys gaumeri was caught in all trapping sites and was the most infected species (63.6%, 7/11). The percentage of infection for O. phyllotis was 44.4% (4/9). Leishmania (Leishmania) mexicana was identified as the infecting species in two H. gaumeri. This study provides, for the first time, evidence of Leishmania infection in wild rodents from the Yucatan state. Heteromys gaumeri and O. phyllotis may be involved in the transmission cycle of L. mexicana in this emergent focus; however, further longitudinal studies are needed to confirm their role as primary reservoirs.http://dx.doi.org/10.1155/2022/8392005 |
| spellingShingle | Erika I. Sosa-Bibiano Luis A. Sánchez -Martínez Karina B. López-Ávila Juan B. Chablé-Santos Jimmy R. Torres-Castro Edith A. Fernández-Figueroa Claudia Rangel-Escareño Elsy N. Loría-Cervera Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico Journal of Tropical Medicine |
| title | Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico |
| title_full | Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico |
| title_fullStr | Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico |
| title_full_unstemmed | Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico |
| title_short | Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico |
| title_sort | leishmania leishmania mexicana infection in wild rodents from an emergent focus of cutaneous leishmaniasis in yucatan mexico |
| url | http://dx.doi.org/10.1155/2022/8392005 |
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