Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population
Abstract Background New type of arrhythmia called atrial high-rate episodes (AHREs) has been discovered thanks to the ability of cardiac electronic implantable devices to track, record, and analyze complex arrhythmias. The aim is to determine factors associated with AHRE in HFrEF/CRT patients and th...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | https://doi.org/10.1186/s43044-025-00613-7 |
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| author | Lamyaa Elsayed Allam Youssef Abdel Moneim Hayam Mohammad Eldamanhoury Sherif Mohammad Aziz Eltoukhy |
| author_facet | Lamyaa Elsayed Allam Youssef Abdel Moneim Hayam Mohammad Eldamanhoury Sherif Mohammad Aziz Eltoukhy |
| author_sort | Lamyaa Elsayed Allam |
| collection | DOAJ |
| description | Abstract Background New type of arrhythmia called atrial high-rate episodes (AHREs) has been discovered thanks to the ability of cardiac electronic implantable devices to track, record, and analyze complex arrhythmias. The aim is to determine factors associated with AHRE in HFrEF/CRT patients and the effect of AHRE on functional capacity and quality of life (QoL). Results We interrogated 100 patients' devices to gauge the incidence and burden of AHRE, then assessed their functional capacity using the standard 6-min walk test (6MWT), and evaluated their QoL using the Minnesota Living with HF questionnaire (MLHFQ) score. 34% of patients had AHRE, and 91.2% of them had AF. By multivariate logistic regression analysis, smoking (OR 9.426, 95% CI [1.33, 66.65], P 0.025), higher BMI (OR 1.336, 95% CI [1.09, 1.635], P 0.005), and increased LAVI (OR 1.16, 95% CI [1.063, 1.262], P < 0.001) are independent predictors for AHRE. There was a significant correlation between AHRE and the distance walked during 6MWT when compared to the distance expected for an equivalent healthy individual (82.02 ± 17.22% in the non-AHRE group vs. 75.15 ± 15.78% in the AHRE group, P < 0.001). It was found that AHRE was statistically linked to a higher total MLHFQ score (46.76 ± 9.82 in the AHRE group vs. 36.97 ± 7.76 in the non-AHRE group, P 0.032), with higher physical scores in the AHRE group. Conclusion AHRE significantly reduces functional status and perceived quality of life in HFrEF patients receiving CRT. Longer than five minutes of AHRE was associated with a higher MLHFQ score and worse performance on the 6MWT. In that patient population, smoking, obesity, and elevated LAVI were independent predictors of AHRE. |
| format | Article |
| id | doaj-art-052dffe3d3d3440994cddb2bcdbfebe1 |
| institution | Kabale University |
| issn | 2090-911X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj-art-052dffe3d3d3440994cddb2bcdbfebe12025-02-09T12:43:16ZengSpringerOpenThe Egyptian Heart Journal2090-911X2025-02-017711910.1186/s43044-025-00613-7Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy populationLamyaa Elsayed Allam0Youssef Abdel Moneim1Hayam Mohammad Eldamanhoury2Sherif Mohammad Aziz Eltoukhy3Cardiology Department, Ain Shams UniversityCardiology Department, Ain Shams UniversityCardiology Department, Ain Shams UniversityCardiology Department, Ain Shams UniversityAbstract Background New type of arrhythmia called atrial high-rate episodes (AHREs) has been discovered thanks to the ability of cardiac electronic implantable devices to track, record, and analyze complex arrhythmias. The aim is to determine factors associated with AHRE in HFrEF/CRT patients and the effect of AHRE on functional capacity and quality of life (QoL). Results We interrogated 100 patients' devices to gauge the incidence and burden of AHRE, then assessed their functional capacity using the standard 6-min walk test (6MWT), and evaluated their QoL using the Minnesota Living with HF questionnaire (MLHFQ) score. 34% of patients had AHRE, and 91.2% of them had AF. By multivariate logistic regression analysis, smoking (OR 9.426, 95% CI [1.33, 66.65], P 0.025), higher BMI (OR 1.336, 95% CI [1.09, 1.635], P 0.005), and increased LAVI (OR 1.16, 95% CI [1.063, 1.262], P < 0.001) are independent predictors for AHRE. There was a significant correlation between AHRE and the distance walked during 6MWT when compared to the distance expected for an equivalent healthy individual (82.02 ± 17.22% in the non-AHRE group vs. 75.15 ± 15.78% in the AHRE group, P < 0.001). It was found that AHRE was statistically linked to a higher total MLHFQ score (46.76 ± 9.82 in the AHRE group vs. 36.97 ± 7.76 in the non-AHRE group, P 0.032), with higher physical scores in the AHRE group. Conclusion AHRE significantly reduces functional status and perceived quality of life in HFrEF patients receiving CRT. Longer than five minutes of AHRE was associated with a higher MLHFQ score and worse performance on the 6MWT. In that patient population, smoking, obesity, and elevated LAVI were independent predictors of AHRE.https://doi.org/10.1186/s43044-025-00613-7Heart failure with reduced ejection fractionCardiac resynchronization therapyAtrial high-rate episodes6-min walk testMinnesota living with heart failure questionnaire |
| spellingShingle | Lamyaa Elsayed Allam Youssef Abdel Moneim Hayam Mohammad Eldamanhoury Sherif Mohammad Aziz Eltoukhy Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population The Egyptian Heart Journal Heart failure with reduced ejection fraction Cardiac resynchronization therapy Atrial high-rate episodes 6-min walk test Minnesota living with heart failure questionnaire |
| title | Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population |
| title_full | Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population |
| title_fullStr | Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population |
| title_full_unstemmed | Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population |
| title_short | Effect of atrial high-rate episodes (AHREs) on functional status and quality of life (QoL) in heart failure—cardiac resynchronization therapy population |
| title_sort | effect of atrial high rate episodes ahres on functional status and quality of life qol in heart failure cardiac resynchronization therapy population |
| topic | Heart failure with reduced ejection fraction Cardiac resynchronization therapy Atrial high-rate episodes 6-min walk test Minnesota living with heart failure questionnaire |
| url | https://doi.org/10.1186/s43044-025-00613-7 |
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