Reprogramming with Small Molecules instead of Exogenous Transcription Factors
Induced pluripotent stem cells (iPSCs) could be employed in the creation of patient-specific stem cells, which could subsequently be used in various basic and clinical applications. However, current iPSC methodologies present significant hidden risks with respect to genetic mutations and abnormal ex...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/794632 |
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| author | Tongxiang Lin Shouhai Wu |
| author_facet | Tongxiang Lin Shouhai Wu |
| author_sort | Tongxiang Lin |
| collection | DOAJ |
| description | Induced pluripotent stem cells (iPSCs) could be employed in the creation of patient-specific stem cells, which could subsequently be used in various basic and clinical applications. However, current iPSC methodologies present significant hidden risks with respect to genetic mutations and abnormal expression which are a barrier in realizing the full potential of iPSCs. A chemical approach is thought to be a promising strategy for safety and efficiency of iPSC generation. Many small molecules have been identified that can be used in place of exogenous transcription factors and significantly improve iPSC reprogramming efficiency and quality. Recent studies have shown that the use of small molecules results in the generation of chemically induced pluripotent stem cells from mouse embryonic fibroblast cells. These studies might lead to new areas of stem cell research and medical applications, not only human iPSC by chemicals alone, but also safe generation of somatic stem cells for cell based clinical trials and other researches. In this paper, we have reviewed the recent advances in small molecule approaches for the generation of iPSCs. |
| format | Article |
| id | doaj-art-051bd72dec93451d81277527ee17ea59 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-051bd72dec93451d81277527ee17ea592025-08-20T02:02:58ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/794632794632Reprogramming with Small Molecules instead of Exogenous Transcription FactorsTongxiang Lin0Shouhai Wu1Guangzhou University of Chinese Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), 55 Neihuan W. Road, Higher Education Mega Center, Guangzhou, Guangdong 510006, ChinaGuangzhou University of Chinese Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), 55 Neihuan W. Road, Higher Education Mega Center, Guangzhou, Guangdong 510006, ChinaInduced pluripotent stem cells (iPSCs) could be employed in the creation of patient-specific stem cells, which could subsequently be used in various basic and clinical applications. However, current iPSC methodologies present significant hidden risks with respect to genetic mutations and abnormal expression which are a barrier in realizing the full potential of iPSCs. A chemical approach is thought to be a promising strategy for safety and efficiency of iPSC generation. Many small molecules have been identified that can be used in place of exogenous transcription factors and significantly improve iPSC reprogramming efficiency and quality. Recent studies have shown that the use of small molecules results in the generation of chemically induced pluripotent stem cells from mouse embryonic fibroblast cells. These studies might lead to new areas of stem cell research and medical applications, not only human iPSC by chemicals alone, but also safe generation of somatic stem cells for cell based clinical trials and other researches. In this paper, we have reviewed the recent advances in small molecule approaches for the generation of iPSCs.http://dx.doi.org/10.1155/2015/794632 |
| spellingShingle | Tongxiang Lin Shouhai Wu Reprogramming with Small Molecules instead of Exogenous Transcription Factors Stem Cells International |
| title | Reprogramming with Small Molecules instead of Exogenous Transcription Factors |
| title_full | Reprogramming with Small Molecules instead of Exogenous Transcription Factors |
| title_fullStr | Reprogramming with Small Molecules instead of Exogenous Transcription Factors |
| title_full_unstemmed | Reprogramming with Small Molecules instead of Exogenous Transcription Factors |
| title_short | Reprogramming with Small Molecules instead of Exogenous Transcription Factors |
| title_sort | reprogramming with small molecules instead of exogenous transcription factors |
| url | http://dx.doi.org/10.1155/2015/794632 |
| work_keys_str_mv | AT tongxianglin reprogrammingwithsmallmoleculesinsteadofexogenoustranscriptionfactors AT shouhaiwu reprogrammingwithsmallmoleculesinsteadofexogenoustranscriptionfactors |