Exploring the pediatric lymphoma landscape: State cancer institute experience
Background: Pediatric lymphoma is the third most prevalent childhood malignancy in India. The diverse nature of lymphoma in the pediatric age group emphasizes the need for personalized treatment strategies. This study aimed to highlight histomorphological subclassification of pediatric lymphoma and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KIMS Foundation and Research Center
2025-03-01
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| Series: | Journal of Medical and Scientific Research |
| Subjects: | |
| Online Access: | https://jmsronline.com/archive-article/Exploring-pediatric-lymphoma-landscape-cancer-institute-experience |
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| Summary: | Background: Pediatric lymphoma is the third most prevalent childhood malignancy in India. The diverse nature of lymphoma in the pediatric age group emphasizes the need for personalized treatment strategies. This study aimed to highlight histomorphological subclassification of pediatric lymphoma and analyze the distribution of nodal and extranodal lymphoma. Materials and
Methods: In a retrospective observational study done over a period of three and a half years, 126 cases of pediatric lymphomas were diagnosed with the help of histomorphology and immunohistochemistry (IHC).
Results: A total of 126 pediatric patients were enrolled in our study. Non-Hodgkin lymphoma (NHL) comprised 53.2% and Hodgkin lymphoma (HL) accounted for 46.8% with a male to female ratio of 2.7:1. T lymphoblastic lymphoma was the most prevalent (46.3%) and thoracic cavity was the most common extranodal site for it. The most common subtype of HL reported was mixed cellularity (56%).
Conclusion: Comprehensive morphological assessment and targeted IHC profiling are essential for precise subclassification of both nodal and extranodal pediatric lymphoma. Recent progress in pediatric lymphoma research has optimized treatment strategies. |
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| ISSN: | 2321-1326 2394-112X |