Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications
Regenerative medicine is an interdisciplinary approach that introduces treatment modalities that mimic natural biological mechanisms. These treatment modalities include growth factors, cytokines modulation of the signaling cascade, and customized tissue engineering therapies with the least invasive...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2025-08-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1971 |
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| author | Hala Adnan Abdul-Hameed Hayder Fadhil Saloom Saleh Johy Jany |
| author_facet | Hala Adnan Abdul-Hameed Hayder Fadhil Saloom Saleh Johy Jany |
| author_sort | Hala Adnan Abdul-Hameed |
| collection | DOAJ |
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Regenerative medicine is an interdisciplinary approach that introduces treatment modalities that mimic natural biological mechanisms. These treatment modalities include growth factors, cytokines modulation of the signaling cascade, and customized tissue engineering therapies with the least invasive methods. Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that enhances granulocyte lineage cell proliferation, differentiation, and activation. Evidence-based studies have analyzed the effect of using recombinant human rh G-CSF on stem cell and progenitor cell recruitment and tissue repair and regeneration via anabolic protein upregulation and antiapoptotic mechanism enhancement. Promising regenerative effects of rh G-CSF administration have been reported in medical fields, such as providing long-term effects of neuroprotection in Parkinson's, Huntington's, and Alzheimer's diseases, ischemic disease, wound healing, diabetic foot repair, cardiovascular disease, reproductive biology, liver disease, and osteoid tissue regeneration.
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| format | Article |
| id | doaj-art-050da362fec14db4b31fb593b08d8494 |
| institution | DOAJ |
| issn | 1810-9543 2521-4365 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj-art-050da362fec14db4b31fb593b08d84942025-08-20T03:16:22ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652025-08-0121210.47723/8exa5y46Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and ApplicationsHala Adnan Abdul-Hameed0https://orcid.org/0000-0001-8811-3808Hayder Fadhil Saloom1https://orcid.org/0000-0001-8922-3769Saleh Johy Jany2https://orcid.org/0009-0002-6946-4674Department of Orthodontic, College of Dentistry, University of Baghdad, IraqDepartment of Orthodontics, College of Dentistry, University of Baghdad, IraqOral and maxillofacial surgeon, George Washington University, Milken Institute of public health Regenerative medicine is an interdisciplinary approach that introduces treatment modalities that mimic natural biological mechanisms. These treatment modalities include growth factors, cytokines modulation of the signaling cascade, and customized tissue engineering therapies with the least invasive methods. Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that enhances granulocyte lineage cell proliferation, differentiation, and activation. Evidence-based studies have analyzed the effect of using recombinant human rh G-CSF on stem cell and progenitor cell recruitment and tissue repair and regeneration via anabolic protein upregulation and antiapoptotic mechanism enhancement. Promising regenerative effects of rh G-CSF administration have been reported in medical fields, such as providing long-term effects of neuroprotection in Parkinson's, Huntington's, and Alzheimer's diseases, ischemic disease, wound healing, diabetic foot repair, cardiovascular disease, reproductive biology, liver disease, and osteoid tissue regeneration. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1971GranulocyteRegenerative medicine rh G-CSF |
| spellingShingle | Hala Adnan Abdul-Hameed Hayder Fadhil Saloom Saleh Johy Jany Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications مجله كليه طب الكندي Granulocyte Regenerative medicine rh G-CSF |
| title | Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications |
| title_full | Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications |
| title_fullStr | Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications |
| title_full_unstemmed | Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications |
| title_short | Regenerative Medicine with Recombinant Human Granulocyte Colony Stimulating Factor: Insights and Applications |
| title_sort | regenerative medicine with recombinant human granulocyte colony stimulating factor insights and applications |
| topic | Granulocyte Regenerative medicine rh G-CSF |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1971 |
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