From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges
Abstract Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammatory response. The symptoms of this disease include a...
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03106-6 |
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| author | Wei Du Xinyue Wang Yuyan Zhou Wencheng Wu Haojie Huang Zhendong Jin |
| author_facet | Wei Du Xinyue Wang Yuyan Zhou Wencheng Wu Haojie Huang Zhendong Jin |
| author_sort | Wei Du |
| collection | DOAJ |
| description | Abstract Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammatory response. The symptoms of this disease include abdominal pain, nausea and vomiting and fever. These symptoms are induced by a hyperinflammatory response and oxidative stress. In recent years, research has focused on developing anti-inflammatory and antioxidative therapies for the treatment of acute pancreatitis (AP). However, there are still limitations to this approach, including poor drug stability, low bioavailability and a short half-life. The advent of nanotechnology has opened up a novel avenue for the management of acute pancreatitis (AP). Nanomaterials can serve as an efficacious vehicle for conventional pharmaceuticals, enhancing their targeting ability, improving bioavailability and prolonging their half-life. Moreover, they can also exert a direct therapeutic effect. This review begins by introducing the general situation of acute pancreatitis (AP). It then discusses the pathogenesis of acute pancreatitis (AP) and the current status of treatment. Finally, it considers the literature related to the treatment of acute pancreatitis (AP) by nanomaterials. The objective of this study is to provide a comprehensive review of the existing literature on the use of nanomaterials in the treatment of acute pancreatitis (AP). In particular, the changes in inflammatory markers and therapeutic outcomes following the administration of nanomaterials are examined. This is done with the intention of offering insights that can inform subsequent research and facilitate the clinical application of nanomaterials in the management of acute pancreatitis (AP). Graphical Abstract |
| format | Article |
| id | doaj-art-050d042fab8444528d76f651d8c7fbc0 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Journal of Nanobiotechnology |
| spelling | doaj-art-050d042fab8444528d76f651d8c7fbc02025-02-02T12:41:00ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112110.1186/s12951-025-03106-6From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emergesWei Du0Xinyue Wang1Yuyan Zhou2Wencheng Wu3Haojie Huang4Zhendong Jin5Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical UniversityDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical UniversityDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical UniversityCentral Laboratory, Department of Medical Ultrasound, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical UniversityDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, National Key Laboratory of Immunity and Inflammation, Changhai Hospital, Naval Medical UniversityAbstract Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammatory response. The symptoms of this disease include abdominal pain, nausea and vomiting and fever. These symptoms are induced by a hyperinflammatory response and oxidative stress. In recent years, research has focused on developing anti-inflammatory and antioxidative therapies for the treatment of acute pancreatitis (AP). However, there are still limitations to this approach, including poor drug stability, low bioavailability and a short half-life. The advent of nanotechnology has opened up a novel avenue for the management of acute pancreatitis (AP). Nanomaterials can serve as an efficacious vehicle for conventional pharmaceuticals, enhancing their targeting ability, improving bioavailability and prolonging their half-life. Moreover, they can also exert a direct therapeutic effect. This review begins by introducing the general situation of acute pancreatitis (AP). It then discusses the pathogenesis of acute pancreatitis (AP) and the current status of treatment. Finally, it considers the literature related to the treatment of acute pancreatitis (AP) by nanomaterials. The objective of this study is to provide a comprehensive review of the existing literature on the use of nanomaterials in the treatment of acute pancreatitis (AP). In particular, the changes in inflammatory markers and therapeutic outcomes following the administration of nanomaterials are examined. This is done with the intention of offering insights that can inform subsequent research and facilitate the clinical application of nanomaterials in the management of acute pancreatitis (AP). Graphical Abstracthttps://doi.org/10.1186/s12951-025-03106-6Acute pancreatitis (AP)NanotechnologyNanomaterialsNanocarriersNanomedicinesTherapy |
| spellingShingle | Wei Du Xinyue Wang Yuyan Zhou Wencheng Wu Haojie Huang Zhendong Jin From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges Journal of Nanobiotechnology Acute pancreatitis (AP) Nanotechnology Nanomaterials Nanocarriers Nanomedicines Therapy |
| title | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges |
| title_full | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges |
| title_fullStr | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges |
| title_full_unstemmed | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges |
| title_short | From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges |
| title_sort | from micro to macro nanotechnology demystifies acute pancreatitis a new generation of treatment options emerges |
| topic | Acute pancreatitis (AP) Nanotechnology Nanomaterials Nanocarriers Nanomedicines Therapy |
| url | https://doi.org/10.1186/s12951-025-03106-6 |
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