Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease
The interest in genetic manipulations of PPARs is as old as their discovery as receptors of ligands with beneficial clinical activities. Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and diabetes, gene kno...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2007/12781 |
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| _version_ | 1849308479048646656 |
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| author | Yaacov Barak Suyeon Kim |
| author_facet | Yaacov Barak Suyeon Kim |
| author_sort | Yaacov Barak |
| collection | DOAJ |
| description | The interest in genetic manipulations of PPARs is as old as their discovery as receptors of ligands with beneficial clinical activities. Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and diabetes, gene knockout (KO) in mice is the ideal platform for both hypothesis testing and discovery of new PPAR functions in vivo. With the fervent pursuit of the magic bullet to eradicate the obesity epidemic, special emphasis has been placed on the impacts of PPARs on obesity and its associated diseases. As detailed in this review, understanding how PPARs regulate gene expression and basic metabolic pathways is a necessary intermediate en route to deciphering their effects on obesity. Over a decade and dozens of genetic modifications of PPARs into this effort, valuable lessons have been learned, but we are left with more questions to be answered. These lessons and future prospects are the subject of this review. |
| format | Article |
| id | doaj-art-050a758776e44c228b4fbf96d2bf6c06 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-050a758776e44c228b4fbf96d2bf6c062025-08-20T03:54:25ZengWileyPPAR Research1687-47571687-47652007-01-01200710.1155/2007/1278112781Genetic Manipulations of PPARs: Effects on Obesity and Metabolic DiseaseYaacov Barak0Suyeon Kim1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USAThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USAThe interest in genetic manipulations of PPARs is as old as their discovery as receptors of ligands with beneficial clinical activities. Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and diabetes, gene knockout (KO) in mice is the ideal platform for both hypothesis testing and discovery of new PPAR functions in vivo. With the fervent pursuit of the magic bullet to eradicate the obesity epidemic, special emphasis has been placed on the impacts of PPARs on obesity and its associated diseases. As detailed in this review, understanding how PPARs regulate gene expression and basic metabolic pathways is a necessary intermediate en route to deciphering their effects on obesity. Over a decade and dozens of genetic modifications of PPARs into this effort, valuable lessons have been learned, but we are left with more questions to be answered. These lessons and future prospects are the subject of this review.http://dx.doi.org/10.1155/2007/12781 |
| spellingShingle | Yaacov Barak Suyeon Kim Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease PPAR Research |
| title | Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease |
| title_full | Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease |
| title_fullStr | Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease |
| title_full_unstemmed | Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease |
| title_short | Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease |
| title_sort | genetic manipulations of ppars effects on obesity and metabolic disease |
| url | http://dx.doi.org/10.1155/2007/12781 |
| work_keys_str_mv | AT yaacovbarak geneticmanipulationsofpparseffectsonobesityandmetabolicdisease AT suyeonkim geneticmanipulationsofpparseffectsonobesityandmetabolicdisease |