Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls
Abstract Background Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. Whether fibromyalgia patients in a mild activity or...
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BMC
2025-01-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08323-6 |
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| author | Yidan Wang Pengxiao Liu Zihao Li Shiya Wu Meijuan Long Yang Li Juan Jiao Zheng Xie |
| author_facet | Yidan Wang Pengxiao Liu Zihao Li Shiya Wu Meijuan Long Yang Li Juan Jiao Zheng Xie |
| author_sort | Yidan Wang |
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| description | Abstract Background Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. Whether fibromyalgia patients in a mild activity or remission stage still experience core symptoms remains unclear. Objective To compare the severity of clinical symptoms and quality of life (QOL) in patients with remission or mild fibromyalgia (RFM) and remission or low disease activity in rheumatoid arthritis (RRA) patients and healthy controls (HCs) to investigate whether fibromyalgia in a stable stage can be disease-free. Methods This cross-sectional study evaluated a total of 266 RFM and 252 RRA patients and 50 HCs using Revised Fibromyalgia Impact Questionnaire (FIQR), Widespread Pain Index (WPI), Pain Visual Analogue Scale (VAS), Numerical Rating Scale, Multidimensional Fatigue Inventory (MFI-20), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI), and Short Form-36 Health Status Questionnaire (SF-36). Results The FIQR total score and pain VAS, MFI, and PSQI scores were higher in RFM and RRA patients compared to HCs (P < 0.001). RFM patients had higher BDI and WPI scores than RRA patients (P < 0.001). The majority of RFM patients (97.4%) had more than two pain sites, with moderate-to-severe pain (78.2%), sleep disorders (85.0%), and depression (53.4%), all of which were significantly higher than those in RRA patients (P < 0.001). RFM patients also had lower scores in SF-36 physical and mental component summaries and subscores for role physical, pain index, general health perception, vitality, and mental health index, but a higher social functioning score than RRA patients (P < 0.001). Conclusion Despite being in a mild activity or remission stage, RFM patients experience more severe symptoms and poorer QOL than RRA patients. Therefore, individualized evaluation and intensive management are required. Trial registration ClinicalTrials.gov Identifier: NCT02449395, registered on May 20, 2015. |
| format | Article |
| id | doaj-art-04fe906197094553830dc0c743feb3e5 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-04fe906197094553830dc0c743feb3e52025-01-19T12:04:38ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-0126111010.1186/s12891-025-08323-6Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controlsYidan Wang0Pengxiao Liu1Zihao Li2Shiya Wu3Meijuan Long4Yang Li5Juan Jiao6Zheng Xie7Rheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital Baoding, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesRheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesGeriatrics Department, Guang’anmen Hospital, China Academy of Chinese Medical SciencesAbstract Background Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals and other rheumatic disease patients, it leads to more severe symptoms and a lower quality of life. Whether fibromyalgia patients in a mild activity or remission stage still experience core symptoms remains unclear. Objective To compare the severity of clinical symptoms and quality of life (QOL) in patients with remission or mild fibromyalgia (RFM) and remission or low disease activity in rheumatoid arthritis (RRA) patients and healthy controls (HCs) to investigate whether fibromyalgia in a stable stage can be disease-free. Methods This cross-sectional study evaluated a total of 266 RFM and 252 RRA patients and 50 HCs using Revised Fibromyalgia Impact Questionnaire (FIQR), Widespread Pain Index (WPI), Pain Visual Analogue Scale (VAS), Numerical Rating Scale, Multidimensional Fatigue Inventory (MFI-20), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI), and Short Form-36 Health Status Questionnaire (SF-36). Results The FIQR total score and pain VAS, MFI, and PSQI scores were higher in RFM and RRA patients compared to HCs (P < 0.001). RFM patients had higher BDI and WPI scores than RRA patients (P < 0.001). The majority of RFM patients (97.4%) had more than two pain sites, with moderate-to-severe pain (78.2%), sleep disorders (85.0%), and depression (53.4%), all of which were significantly higher than those in RRA patients (P < 0.001). RFM patients also had lower scores in SF-36 physical and mental component summaries and subscores for role physical, pain index, general health perception, vitality, and mental health index, but a higher social functioning score than RRA patients (P < 0.001). Conclusion Despite being in a mild activity or remission stage, RFM patients experience more severe symptoms and poorer QOL than RRA patients. Therefore, individualized evaluation and intensive management are required. Trial registration ClinicalTrials.gov Identifier: NCT02449395, registered on May 20, 2015.https://doi.org/10.1186/s12891-025-08323-6FibromyalgiaRemissionSeverity of illness indexSymptom burdenQuality of life |
| spellingShingle | Yidan Wang Pengxiao Liu Zihao Li Shiya Wu Meijuan Long Yang Li Juan Jiao Zheng Xie Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls BMC Musculoskeletal Disorders Fibromyalgia Remission Severity of illness index Symptom burden Quality of life |
| title | Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| title_full | Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| title_fullStr | Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| title_full_unstemmed | Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| title_short | Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| title_sort | quality of life pain depression fatigue and sleep in patients with remission or mild fibromyalgia a comparison with remission or low disease activity rheumatoid arthritis and healthy controls |
| topic | Fibromyalgia Remission Severity of illness index Symptom burden Quality of life |
| url | https://doi.org/10.1186/s12891-025-08323-6 |
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