Critical evaluation of pathogenic factors of primary biliary cirrhosis
The aim of review. Primary biliary cirrhosis (PBC) is related to the group of autoimmune cholestasisassociated liver diseases. In the last years prevalence of PBC increased considerably, especially – in Northern European countries. Despite of sufficient progress in studying of main pathophysiologica...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2013-07-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1203 |
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| _version_ | 1823860173820657664 |
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| author | A. F. Sheptulina M. V. Mayevskaya V. T. Ivashkin |
| author_facet | A. F. Sheptulina M. V. Mayevskaya V. T. Ivashkin |
| author_sort | A. F. Sheptulina |
| collection | DOAJ |
| description | The aim of review. Primary biliary cirrhosis (PBC) is related to the group of autoimmune cholestasisassociated liver diseases. In the last years prevalence of PBC increased considerably, especially – in Northern European countries. Despite of sufficient progress in studying of main pathophysiological mechanisms of PBC, etiology of disease remains obscure. There was a task to fill these gaps to some extent.Key points. Etiological factors increasing risk of PBC development include genetic factors, immunologic disorders, and environmental features. Thus the contribution of each of the mentioned groups of factors, at least, partly is determined by demographic, ethnic and geographical features.Conclusion. Detection of risk factors and the possible PBC causes allows to develop additional treatment approaches, and define new PBC markers, increase rate of early stage diagnostics. |
| format | Article |
| id | doaj-art-04fce8ba46d44b8b8bafcdbc9bcfb492 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2013-07-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-04fce8ba46d44b8b8bafcdbc9bcfb4922025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732013-07-012333948787Critical evaluation of pathogenic factors of primary biliary cirrhosisA. F. Sheptulina0M. V. Mayevskaya1V. T. Ivashkin2State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationThe aim of review. Primary biliary cirrhosis (PBC) is related to the group of autoimmune cholestasisassociated liver diseases. In the last years prevalence of PBC increased considerably, especially – in Northern European countries. Despite of sufficient progress in studying of main pathophysiological mechanisms of PBC, etiology of disease remains obscure. There was a task to fill these gaps to some extent.Key points. Etiological factors increasing risk of PBC development include genetic factors, immunologic disorders, and environmental features. Thus the contribution of each of the mentioned groups of factors, at least, partly is determined by demographic, ethnic and geographical features.Conclusion. Detection of risk factors and the possible PBC causes allows to develop additional treatment approaches, and define new PBC markers, increase rate of early stage diagnostics.https://www.gastro-j.ru/jour/article/view/1203primary biliary cirrhosischolangiopathycholestasismain histocompatibility complexpyruvate dehydrogenase complexantimitochondrial antibodiesantinuclear antibodies |
| spellingShingle | A. F. Sheptulina M. V. Mayevskaya V. T. Ivashkin Critical evaluation of pathogenic factors of primary biliary cirrhosis Российский журнал гастроэнтерологии, гепатологии, колопроктологии primary biliary cirrhosis cholangiopathy cholestasis main histocompatibility complex pyruvate dehydrogenase complex antimitochondrial antibodies antinuclear antibodies |
| title | Critical evaluation of pathogenic factors of primary biliary cirrhosis |
| title_full | Critical evaluation of pathogenic factors of primary biliary cirrhosis |
| title_fullStr | Critical evaluation of pathogenic factors of primary biliary cirrhosis |
| title_full_unstemmed | Critical evaluation of pathogenic factors of primary biliary cirrhosis |
| title_short | Critical evaluation of pathogenic factors of primary biliary cirrhosis |
| title_sort | critical evaluation of pathogenic factors of primary biliary cirrhosis |
| topic | primary biliary cirrhosis cholangiopathy cholestasis main histocompatibility complex pyruvate dehydrogenase complex antimitochondrial antibodies antinuclear antibodies |
| url | https://www.gastro-j.ru/jour/article/view/1203 |
| work_keys_str_mv | AT afsheptulina criticalevaluationofpathogenicfactorsofprimarybiliarycirrhosis AT mvmayevskaya criticalevaluationofpathogenicfactorsofprimarybiliarycirrhosis AT vtivashkin criticalevaluationofpathogenicfactorsofprimarybiliarycirrhosis |