A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension
ObjectiveTo investigate the association between triglyceride-glucose (TyG) index and the risk of stroke in middle-aged and elderly individuals with hypertension, so as to provide more evidence for the prevention and treatment of stroke.MethodsMiddle-aged and elderly hypertensive individuals who took...
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Shanghai Preventive Medicine Association
2025-05-01
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| Series: | Shanghai yufang yixue |
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| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24453 |
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| author | CHEN Hongyan FANG Kui ZHANG Jie |
| author_facet | CHEN Hongyan FANG Kui ZHANG Jie |
| author_sort | CHEN Hongyan |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between triglyceride-glucose (TyG) index and the risk of stroke in middle-aged and elderly individuals with hypertension, so as to provide more evidence for the prevention and treatment of stroke.MethodsMiddle-aged and elderly hypertensive individuals who took part in all four surveys in 2011, 2013, 2015, and 2018 were selected as the research subjects based on data from the China Health and Retirement Longitudinal Study (CHARLS). Participants were divided into four groups (≤Q1， >Q1~Q2， >Q2~Q3， and >Q3) based on TyG index quartiles, and the cumulative risk of stroke in different groups was analyzed using the Kaplan-Meier method. Different Cox proportional hazards regression models were constructed to analyze the relationship between the TyG index and stroke risk. Sensitivity analysis were performed to evaluate the robustness of the results.ResultsA total of 4 596 participants were included in the study. Among them, 338 individuals (7.35%) had a stroke during the 7-year follow-up period. The cumulative risk of stroke increased with higher TyG index levels. Results from the Cox regression models indicated that higher TyG levels were associated with an increased risk of stroke among middle-aged and elderly individuals with hypertension. Compared with the lowest TyG index quartile (≤Q1: TyG index ≤8.33) group, the highest quartile (>Q3: TyG index >9.17) group showed a 45.10% increased risk of stroke (HR=1.451, 95% CI:1.017‒2.072).ConclusionA higher TyG index is associated with an increased risk of stroke in middle-aged and elderly individuals with hypertension. |
| format | Article |
| id | doaj-art-04f9db9b98a040b2b30466ea6381f44e |
| institution | DOAJ |
| issn | 1004-9231 |
| language | zho |
| publishDate | 2025-05-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj-art-04f9db9b98a040b2b30466ea6381f44e2025-08-20T03:08:22ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312025-05-0137543644010.19428/j.cnki.sjpm.2025.244531004-9231（2025）05-0436-05A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertensionCHEN Hongyan0FANG Kui1ZHANG Jie2The First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaThe First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaThe First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaObjectiveTo investigate the association between triglyceride-glucose (TyG) index and the risk of stroke in middle-aged and elderly individuals with hypertension, so as to provide more evidence for the prevention and treatment of stroke.MethodsMiddle-aged and elderly hypertensive individuals who took part in all four surveys in 2011, 2013, 2015, and 2018 were selected as the research subjects based on data from the China Health and Retirement Longitudinal Study (CHARLS). Participants were divided into four groups (≤Q1， >Q1~Q2， >Q2~Q3， and >Q3) based on TyG index quartiles, and the cumulative risk of stroke in different groups was analyzed using the Kaplan-Meier method. Different Cox proportional hazards regression models were constructed to analyze the relationship between the TyG index and stroke risk. Sensitivity analysis were performed to evaluate the robustness of the results.ResultsA total of 4 596 participants were included in the study. Among them, 338 individuals (7.35%) had a stroke during the 7-year follow-up period. The cumulative risk of stroke increased with higher TyG index levels. Results from the Cox regression models indicated that higher TyG levels were associated with an increased risk of stroke among middle-aged and elderly individuals with hypertension. Compared with the lowest TyG index quartile (≤Q1: TyG index ≤8.33) group, the highest quartile (>Q3: TyG index >9.17) group showed a 45.10% increased risk of stroke (HR=1.451, 95% CI:1.017‒2.072).ConclusionA higher TyG index is associated with an increased risk of stroke in middle-aged and elderly individuals with hypertension.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24453triglyceride-glucose indexmiddle and old agehypertensionstrokecohort study |
| spellingShingle | CHEN Hongyan FANG Kui ZHANG Jie A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension Shanghai yufang yixue triglyceride-glucose index middle and old age hypertension stroke cohort study |
| title | A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension |
| title_full | A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension |
| title_fullStr | A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension |
| title_full_unstemmed | A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension |
| title_short | A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension |
| title_sort | cohort study of triglyceride glucose index and risk of stroke in middle aged and elderly individuals with hypertension |
| topic | triglyceride-glucose index middle and old age hypertension stroke cohort study |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24453 |
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