Toward spatial glycomics and glycoproteomics: Innovations and applications
In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field. An agile development approach enables unraveling aberrant glycosylation...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | BBA Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160325000092 |
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| author | Patcharaporn Boottanun Sayaka Fuseya Atsushi Kuno |
| author_facet | Patcharaporn Boottanun Sayaka Fuseya Atsushi Kuno |
| author_sort | Patcharaporn Boottanun |
| collection | DOAJ |
| description | In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field. An agile development approach enables unraveling aberrant glycosylations, glycobiomarkers, and glycotargets for spatial imaging, diagnosis, and therapeutic purposes. We discuss glycopathology and tissue glycomic profiling using highly sensitive lectin-based analyses and introduce deep visual proteomics for glycomic/glycoproteomic sample preparation. Additionally, we highlight the importance of leveraging laser microdissection and artificial intelligence-driven visual software for cell-type assignment and automation techniques, which are crucial for advancing glycomics/glycoproteomics. |
| format | Article |
| id | doaj-art-04defebf60d24614adf2fe42842a7e6b |
| institution | Kabale University |
| issn | 2667-1603 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj-art-04defebf60d24614adf2fe42842a7e6b2025-02-12T05:33:04ZengElsevierBBA Advances2667-16032025-01-017100146Toward spatial glycomics and glycoproteomics: Innovations and applicationsPatcharaporn Boottanun0Sayaka Fuseya1Atsushi Kuno2Molecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan; Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo 192-8577, JapanMolecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, JapanMolecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan; Corresponding author at.In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field. An agile development approach enables unraveling aberrant glycosylations, glycobiomarkers, and glycotargets for spatial imaging, diagnosis, and therapeutic purposes. We discuss glycopathology and tissue glycomic profiling using highly sensitive lectin-based analyses and introduce deep visual proteomics for glycomic/glycoproteomic sample preparation. Additionally, we highlight the importance of leveraging laser microdissection and artificial intelligence-driven visual software for cell-type assignment and automation techniques, which are crucial for advancing glycomics/glycoproteomics.http://www.sciencedirect.com/science/article/pii/S2667160325000092Automated analysisArtificial intelligenceGlycomicsGlycoproteomicsImaging mass cytometryLectin microarray |
| spellingShingle | Patcharaporn Boottanun Sayaka Fuseya Atsushi Kuno Toward spatial glycomics and glycoproteomics: Innovations and applications BBA Advances Automated analysis Artificial intelligence Glycomics Glycoproteomics Imaging mass cytometry Lectin microarray |
| title | Toward spatial glycomics and glycoproteomics: Innovations and applications |
| title_full | Toward spatial glycomics and glycoproteomics: Innovations and applications |
| title_fullStr | Toward spatial glycomics and glycoproteomics: Innovations and applications |
| title_full_unstemmed | Toward spatial glycomics and glycoproteomics: Innovations and applications |
| title_short | Toward spatial glycomics and glycoproteomics: Innovations and applications |
| title_sort | toward spatial glycomics and glycoproteomics innovations and applications |
| topic | Automated analysis Artificial intelligence Glycomics Glycoproteomics Imaging mass cytometry Lectin microarray |
| url | http://www.sciencedirect.com/science/article/pii/S2667160325000092 |
| work_keys_str_mv | AT patcharapornboottanun towardspatialglycomicsandglycoproteomicsinnovationsandapplications AT sayakafuseya towardspatialglycomicsandglycoproteomicsinnovationsandapplications AT atsushikuno towardspatialglycomicsandglycoproteomicsinnovationsandapplications |