Efficacy of cardioneuroablation for vasodepressor vasovagal syncope
ObjectiveCardioneuroablation (CNA) is effective for cardiac inhibitory and mixed vasovagal syncope (VVS) but not for vasodepressor VVS. This study aimed to assess the therapeutic benefits of CNA in vasodepressor VVS.MethodsVVS patients hospitalized in the Department of Cardiology of Jiangxi Provinci...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1514513/full |
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| author | Zhenhuan Chen Ying Li Ying Li Yuan Liu Guowang Shen Ganwei Xiong Bo Wu Yanfeng Liu Xiantao Huang Hongyan Li Haiwen Zhou Zhicheng Xu Gulao Zhang Yu Tao Fanzhi Zhang Hengli Lai |
| author_facet | Zhenhuan Chen Ying Li Ying Li Yuan Liu Guowang Shen Ganwei Xiong Bo Wu Yanfeng Liu Xiantao Huang Hongyan Li Haiwen Zhou Zhicheng Xu Gulao Zhang Yu Tao Fanzhi Zhang Hengli Lai |
| author_sort | Zhenhuan Chen |
| collection | DOAJ |
| description | ObjectiveCardioneuroablation (CNA) is effective for cardiac inhibitory and mixed vasovagal syncope (VVS) but not for vasodepressor VVS. This study aimed to assess the therapeutic benefits of CNA in vasodepressor VVS.MethodsVVS patients hospitalized in the Department of Cardiology of Jiangxi Provincial People’s Hospital were retrospectively reviewed. Holter monitoring was performed before, during, and 3 months after CNA. Changes in heart rate and atrioventricular conduction before and after ablation were compared.ResultsThirty-five patients (18 M/17F, 47.48 ± 16.49 years) were included. Median duration of syncope was 24.0 months (range, 2.5–66.0). Median number of syncope episodes before treatment was two (range, 2–4). The time domain indexes of heart rate variability, mean heart rate, maximum heart rate, and minimum heart rate were significantly higher 3 months after CNA. Mean follow-up was 11 ± 4.67 months. Recurrent syncope occurred in two patients with vasodepressor VVS, one of them with presyncope symptoms in vasodepressor type; and one patient occurred with mixed VVS, without presyncope symptoms. The syncope free survival is 76.92%. No serious complications occurred. CNA is safe and effective in the treatment of vasodepressor VVS.ConclusionCNA is effective for treating vasodepressor VVS. Our study provides a theoretical basis for individualization of treatment in patients with vasodepressor VVS. |
| format | Article |
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| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-04daaa73e48843b98f3a4bf044d5b8f52025-08-20T03:07:27ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-04-011910.3389/fnins.2025.15145131514513Efficacy of cardioneuroablation for vasodepressor vasovagal syncopeZhenhuan Chen0Ying Li1Ying Li2Yuan Liu3Guowang Shen4Ganwei Xiong5Bo Wu6Yanfeng Liu7Xiantao Huang8Hongyan Li9Haiwen Zhou10Zhicheng Xu11Gulao Zhang12Yu Tao13Fanzhi Zhang14Hengli Lai15Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaThe First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaObjectiveCardioneuroablation (CNA) is effective for cardiac inhibitory and mixed vasovagal syncope (VVS) but not for vasodepressor VVS. This study aimed to assess the therapeutic benefits of CNA in vasodepressor VVS.MethodsVVS patients hospitalized in the Department of Cardiology of Jiangxi Provincial People’s Hospital were retrospectively reviewed. Holter monitoring was performed before, during, and 3 months after CNA. Changes in heart rate and atrioventricular conduction before and after ablation were compared.ResultsThirty-five patients (18 M/17F, 47.48 ± 16.49 years) were included. Median duration of syncope was 24.0 months (range, 2.5–66.0). Median number of syncope episodes before treatment was two (range, 2–4). The time domain indexes of heart rate variability, mean heart rate, maximum heart rate, and minimum heart rate were significantly higher 3 months after CNA. Mean follow-up was 11 ± 4.67 months. Recurrent syncope occurred in two patients with vasodepressor VVS, one of them with presyncope symptoms in vasodepressor type; and one patient occurred with mixed VVS, without presyncope symptoms. The syncope free survival is 76.92%. No serious complications occurred. CNA is safe and effective in the treatment of vasodepressor VVS.ConclusionCNA is effective for treating vasodepressor VVS. Our study provides a theoretical basis for individualization of treatment in patients with vasodepressor VVS.https://www.frontiersin.org/articles/10.3389/fnins.2025.1514513/fullvasovagal syncopeleft atrial vagal plexushigh frequency stimulationradiofrequency ablationheart rate variability |
| spellingShingle | Zhenhuan Chen Ying Li Ying Li Yuan Liu Guowang Shen Ganwei Xiong Bo Wu Yanfeng Liu Xiantao Huang Hongyan Li Haiwen Zhou Zhicheng Xu Gulao Zhang Yu Tao Fanzhi Zhang Hengli Lai Efficacy of cardioneuroablation for vasodepressor vasovagal syncope Frontiers in Neuroscience vasovagal syncope left atrial vagal plexus high frequency stimulation radiofrequency ablation heart rate variability |
| title | Efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| title_full | Efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| title_fullStr | Efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| title_full_unstemmed | Efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| title_short | Efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| title_sort | efficacy of cardioneuroablation for vasodepressor vasovagal syncope |
| topic | vasovagal syncope left atrial vagal plexus high frequency stimulation radiofrequency ablation heart rate variability |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1514513/full |
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