Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus
Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease. It has been established that clinical manifestations of APS can persist, progress over time, or debut during an adeq...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-10-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/1205 |
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| author | K. S. Nurbaeva T. M. Reshetnyak A. M. Lila |
| author_facet | K. S. Nurbaeva T. M. Reshetnyak A. M. Lila |
| author_sort | K. S. Nurbaeva |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease. It has been established that clinical manifestations of APS can persist, progress over time, or debut during an adequate anticoagulant therapy and, in some cases, require administration of immunosuppressive drugs, which indicates the role of autoimmune inflammation in their development. The formation of extracellular neutrophil traps (neutrophil extracellular traps, NETs) is one of the connecting links of inflammation and thrombosis. Netosis is the process by which activated neutrophils in the extracellular space form netlike structures (NETs). This review examines the role of neutrophils and netosis in the pathogenesis of APS and SLE. |
| format | Article |
| id | doaj-art-04d6ce1d2b094db889fba445eaea4b26 |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-04d6ce1d2b094db889fba445eaea4b262025-08-20T03:44:21ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-10-011559610210.14412/1996-7012-2021-5-96-1022410Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosusK. S. Nurbaeva0T. M. Reshetnyak1A. M. Lila2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional EducationV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional EducationAntiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease. It has been established that clinical manifestations of APS can persist, progress over time, or debut during an adequate anticoagulant therapy and, in some cases, require administration of immunosuppressive drugs, which indicates the role of autoimmune inflammation in their development. The formation of extracellular neutrophil traps (neutrophil extracellular traps, NETs) is one of the connecting links of inflammation and thrombosis. Netosis is the process by which activated neutrophils in the extracellular space form netlike structures (NETs). This review examines the role of neutrophils and netosis in the pathogenesis of APS and SLE.https://mrj.ima-press.net/mrj/article/view/1205netosisextracellular neutrophil trapsthrombus inflammationantiphospholipid syndromesystemic lupus erythematosus |
| spellingShingle | K. S. Nurbaeva T. M. Reshetnyak A. M. Lila Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus Современная ревматология netosis extracellular neutrophil traps thrombus inflammation antiphospholipid syndrome systemic lupus erythematosus |
| title | Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| title_full | Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| title_fullStr | Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| title_full_unstemmed | Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| title_short | Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| title_sort | netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus |
| topic | netosis extracellular neutrophil traps thrombus inflammation antiphospholipid syndrome systemic lupus erythematosus |
| url | https://mrj.ima-press.net/mrj/article/view/1205 |
| work_keys_str_mv | AT ksnurbaeva netosisinthepathogenesisofantiphospholipidsyndromeandsystemiclupuserythematosus AT tmreshetnyak netosisinthepathogenesisofantiphospholipidsyndromeandsystemiclupuserythematosus AT amlila netosisinthepathogenesisofantiphospholipidsyndromeandsystemiclupuserythematosus |