Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging
Photoacoustic imaging (PAI) shows promise for skin cancer diagnosis by detecting chromophores like melanin, hemoglobin, lipids, and collagen. While most studies focus on malignant lesions, understanding normal skin variability across anatomical regions is crucial for validating PAI's clinical a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Photoacoustics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597925000126 |
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| author | Terese von Knorring Tobias Buhl Ihlemann Paul Blanche Charlene Reichl Niels Møller Israelsen Caroline Meyer Olesen Yasemin Topal Yüksel Mette Mogensen |
| author_facet | Terese von Knorring Tobias Buhl Ihlemann Paul Blanche Charlene Reichl Niels Møller Israelsen Caroline Meyer Olesen Yasemin Topal Yüksel Mette Mogensen |
| author_sort | Terese von Knorring |
| collection | DOAJ |
| description | Photoacoustic imaging (PAI) shows promise for skin cancer diagnosis by detecting chromophores like melanin, hemoglobin, lipids, and collagen. While most studies focus on malignant lesions, understanding normal skin variability across anatomical regions is crucial for validating PAI's clinical application and its use in melanoma diagnosis. We assessed normal skin in 20 healthy volunteers from three different body locations using a clinical PAI system and compared suspicious looking pigmented skin lesions, including melanomas, to adjacent normal skin (n = 74). Higher deoxyhemoglobin levels were observed in the ankle compared to the cheek and volar forearm, while melanin, lipids, and collagen showed minimal variation. Patients with malignant lesions had significantly higher deoxyhemoglobin levels (p = 0.001) than adjacent normal skin, a difference not seen in benign lesions. These findings suggest that PAI may help diagnose malignancies by identifying increased vascularity in skin cancers, while anatomical differences should be considered during diagnostic work-up. |
| format | Article |
| id | doaj-art-04d49041fffe47669a238c5d9163f0c5 |
| institution | Kabale University |
| issn | 2213-5979 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj-art-04d49041fffe47669a238c5d9163f0c52025-02-02T05:27:10ZengElsevierPhotoacoustics2213-59792025-04-0142100693Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imagingTerese von Knorring0Tobias Buhl Ihlemann1Paul Blanche2Charlene Reichl3Niels Møller Israelsen4Caroline Meyer Olesen5Yasemin Topal Yüksel6Mette Mogensen7Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; Corresponding author.Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, DenmarkSection of Biostatistics, University of Copenhagen, Copenhagen, DenmarkiThera Medical GmbH, Munich, GermanyDTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, Kongens Lyngby, DenmarkDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; Dept of Clinical Medicine, University of Copenhagen, DenmarkPhotoacoustic imaging (PAI) shows promise for skin cancer diagnosis by detecting chromophores like melanin, hemoglobin, lipids, and collagen. While most studies focus on malignant lesions, understanding normal skin variability across anatomical regions is crucial for validating PAI's clinical application and its use in melanoma diagnosis. We assessed normal skin in 20 healthy volunteers from three different body locations using a clinical PAI system and compared suspicious looking pigmented skin lesions, including melanomas, to adjacent normal skin (n = 74). Higher deoxyhemoglobin levels were observed in the ankle compared to the cheek and volar forearm, while melanin, lipids, and collagen showed minimal variation. Patients with malignant lesions had significantly higher deoxyhemoglobin levels (p = 0.001) than adjacent normal skin, a difference not seen in benign lesions. These findings suggest that PAI may help diagnose malignancies by identifying increased vascularity in skin cancers, while anatomical differences should be considered during diagnostic work-up.http://www.sciencedirect.com/science/article/pii/S2213597925000126MelanomaPhotoacoustic imagingPigmented lesionsSkin cancerDiagnosticsNoninvasive |
| spellingShingle | Terese von Knorring Tobias Buhl Ihlemann Paul Blanche Charlene Reichl Niels Møller Israelsen Caroline Meyer Olesen Yasemin Topal Yüksel Mette Mogensen Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging Photoacoustics Melanoma Photoacoustic imaging Pigmented lesions Skin cancer Diagnostics Noninvasive |
| title | Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging |
| title_full | Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging |
| title_fullStr | Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging |
| title_full_unstemmed | Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging |
| title_short | Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging |
| title_sort | normal and melanoma skin visualized quantified and compared by in vivo photoacoustic imaging |
| topic | Melanoma Photoacoustic imaging Pigmented lesions Skin cancer Diagnostics Noninvasive |
| url | http://www.sciencedirect.com/science/article/pii/S2213597925000126 |
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