Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i>
The cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number of products now incorporate extracts or isolated compounds from various macroalgae spec...
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MDPI AG
2025-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/2/83 |
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| author | Gonçalo P. Rosa Maria Carmo Barreto Ana M. L. Seca Diana C. G. A. Pinto |
| author_facet | Gonçalo P. Rosa Maria Carmo Barreto Ana M. L. Seca Diana C. G. A. Pinto |
| author_sort | Gonçalo P. Rosa |
| collection | DOAJ |
| description | The cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number of products now incorporate extracts or isolated compounds from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity for further research. Among these, <i>Caulerpa prolifera</i> (Forsskål) J.V. Lamouroux has emerged as a promising candidate for cosmeceutical applications. This study provides the most comprehensive phytochemical assessment of <i>C. prolifera</i> to date, revealing its potential as a source of bioactive extracts and compounds. The analysis identified key components of its lipophilic profile, predominantly saturated and unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate—an endocrine disruptor potentially biosynthesized or bioaccumulated by the algae. While the crude extract exhibited moderate tyrosinase inhibitory activity, its overall antioxidant capacity was limited. Fractionation of the extract, however, yielded subfractions with distinct bioactivities linked to changes in chemical composition. Notably, enhanced inhibitory activities against elastase and collagenase were observed in subfractions enriched with 1-octadecanol and only traces of phthalate. Conversely, antioxidant activity diminished with the loss of specific compounds such as β-sitosterol, erucic acid, nervonic acid, and lignoceric acid. This work advances the understanding of the relationship between the chemical composition of <i>C. prolifera</i> and its bioactivities, emphasizing its potential as a source of cosmeceutical ingredients, leading to a more comprehensive valorization of this macroalga. |
| format | Article |
| id | doaj-art-04ceedda38f948a69f1c3a20f0f729c1 |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-04ceedda38f948a69f1c3a20f0f729c12025-08-20T02:03:25ZengMDPI AGMarine Drugs1660-33972025-02-012328310.3390/md23020083Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i>Gonçalo P. Rosa0Maria Carmo Barreto1Ana M. L. Seca2Diana C. G. A. Pinto3University of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, PortugalUniversity of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, PortugalUniversity of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, PortugalLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, PortugalThe cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number of products now incorporate extracts or isolated compounds from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity for further research. Among these, <i>Caulerpa prolifera</i> (Forsskål) J.V. Lamouroux has emerged as a promising candidate for cosmeceutical applications. This study provides the most comprehensive phytochemical assessment of <i>C. prolifera</i> to date, revealing its potential as a source of bioactive extracts and compounds. The analysis identified key components of its lipophilic profile, predominantly saturated and unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate—an endocrine disruptor potentially biosynthesized or bioaccumulated by the algae. While the crude extract exhibited moderate tyrosinase inhibitory activity, its overall antioxidant capacity was limited. Fractionation of the extract, however, yielded subfractions with distinct bioactivities linked to changes in chemical composition. Notably, enhanced inhibitory activities against elastase and collagenase were observed in subfractions enriched with 1-octadecanol and only traces of phthalate. Conversely, antioxidant activity diminished with the loss of specific compounds such as β-sitosterol, erucic acid, nervonic acid, and lignoceric acid. This work advances the understanding of the relationship between the chemical composition of <i>C. prolifera</i> and its bioactivities, emphasizing its potential as a source of cosmeceutical ingredients, leading to a more comprehensive valorization of this macroalga.https://www.mdpi.com/1660-3397/23/2/83macroalgaephytochemical profilecosmeceutical potential |
| spellingShingle | Gonçalo P. Rosa Maria Carmo Barreto Ana M. L. Seca Diana C. G. A. Pinto Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> Marine Drugs macroalgae phytochemical profile cosmeceutical potential |
| title | Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> |
| title_full | Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> |
| title_fullStr | Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> |
| title_full_unstemmed | Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> |
| title_short | Antiaging Potential of Lipophilic Extracts of <i>Caulerpa prolifera</i> |
| title_sort | antiaging potential of lipophilic extracts of i caulerpa prolifera i |
| topic | macroalgae phytochemical profile cosmeceutical potential |
| url | https://www.mdpi.com/1660-3397/23/2/83 |
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