Research Development of Radiation-Induced Lymphopenia
When radiotherapy is administered, many patients exhibit a reduction in lymphocyte numbers due to the inherent radio-sensitivity of lymphocytes. In particular, they experience a decrease in CD8+ T cells, which may weaken their mediated antitumor immune response. While radiotherapy activates the immu...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2025-04-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0998 |
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| author | Yue WANG Hui ZHU |
| author_facet | Yue WANG Hui ZHU |
| author_sort | Yue WANG |
| collection | DOAJ |
| description | When radiotherapy is administered, many patients exhibit a reduction in lymphocyte numbers due to the inherent radio-sensitivity of lymphocytes. In particular, they experience a decrease in CD8+ T cells, which may weaken their mediated antitumor immune response. While radiotherapy activates the immune system, it can also lead to a certain degree of immunosuppression. Current research suggests that the formation mechanism of radiation-induced lymphopenia (RIL) involves multiple factors, including increased radiation exposure to lymphocytes and the application of lymphocytotoxic drugs. The adverse impact of RIL on patients’ clinical outcomes can be mitigated, to some extent, by actively optimizing radiotherapy dosimetric parameters to maximally protect lymphocytes. |
| format | Article |
| id | doaj-art-04cde19e38974b1b9fd60bdbf122f2bf |
| institution | OA Journals |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-04cde19e38974b1b9fd60bdbf122f2bf2025-08-20T02:28:24ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-04-0152433734110.3971/j.issn.1000-8578.2025.24.099820240998Research Development of Radiation-Induced LymphopeniaYue WANG0Hui ZHU1Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400037, ChinaDepartment of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400037, ChinaWhen radiotherapy is administered, many patients exhibit a reduction in lymphocyte numbers due to the inherent radio-sensitivity of lymphocytes. In particular, they experience a decrease in CD8+ T cells, which may weaken their mediated antitumor immune response. While radiotherapy activates the immune system, it can also lead to a certain degree of immunosuppression. Current research suggests that the formation mechanism of radiation-induced lymphopenia (RIL) involves multiple factors, including increased radiation exposure to lymphocytes and the application of lymphocytotoxic drugs. The adverse impact of RIL on patients’ clinical outcomes can be mitigated, to some extent, by actively optimizing radiotherapy dosimetric parameters to maximally protect lymphocytes.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0998radiation-induced lymphopeniaradiotherapyabsolute lymphocyte counts |
| spellingShingle | Yue WANG Hui ZHU Research Development of Radiation-Induced Lymphopenia Zhongliu Fangzhi Yanjiu radiation-induced lymphopenia radiotherapy absolute lymphocyte counts |
| title | Research Development of Radiation-Induced Lymphopenia |
| title_full | Research Development of Radiation-Induced Lymphopenia |
| title_fullStr | Research Development of Radiation-Induced Lymphopenia |
| title_full_unstemmed | Research Development of Radiation-Induced Lymphopenia |
| title_short | Research Development of Radiation-Induced Lymphopenia |
| title_sort | research development of radiation induced lymphopenia |
| topic | radiation-induced lymphopenia radiotherapy absolute lymphocyte counts |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0998 |
| work_keys_str_mv | AT yuewang researchdevelopmentofradiationinducedlymphopenia AT huizhu researchdevelopmentofradiationinducedlymphopenia |