Pancreatic β‐cell Function is Higher in Morning Versus Intermediate Chronotypes With Obesity
ABSTRACT Objectives People with later chronotypes are at greater T2D risk, yet it is unknown if β‐cell function differs among chronotypes. Thus we, assessed β‐cell function in morning (MORN) and intermediate (INT) chronotypes with obesity. Methods Adults (n = 41, 9M, 55 ± 1.7 y, 36.8 ± 1.0 kg/m2) we...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
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| Series: | Obesity Science & Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/osp4.70064 |
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| Summary: | ABSTRACT Objectives People with later chronotypes are at greater T2D risk, yet it is unknown if β‐cell function differs among chronotypes. Thus we, assessed β‐cell function in morning (MORN) and intermediate (INT) chronotypes with obesity. Methods Adults (n = 41, 9M, 55 ± 1.7 y, 36.8 ± 1.0 kg/m2) were grouped as MORN or INT per the Morningness‐Eveningness Questionnaire. Glucose, insulin, C‐peptide, GIP, and GLP‐1(active) were collected every 30 min during a 120 min 75g‐OGTT. Insulin secretion rates (ISR) were calculated (regularized deconvolution) to assess early (total area under the curve; tAUC0–30min) and total‐phase (tAUC0–120min) glucose‐stimulated insulin secretion (GSIS:ISR/Glucose). Skeletal muscle (glucose infusion rate/steady‐state insulin) insulin sensitivity and hepatic (HOMA‐IR) as well as adipose (Adipose‐IR) insulin resistance were assessed during a 120 min euglycemic hyperinsulinemic clamp (40mU/m2/min, 90 mg/dL). β‐cell function (disposition index (DI): GSIS adjusted insulin sensitivity) was determined. Body composition (DXA) and fitness (VO2max) were also measured. Results Age, body composition and VO2max were similar between groups, but INT had reduced muscle insulin sensitivity and higher hepatic and adipose IR (p < 0.05). INT had higher C‐peptide tAUC0–30min (p = 0.04) and lower hepatic DI (tAUC0–30min p = 0.05 and tAUC0–120min p = 0.07, respectively). Early phase hepatic DI correlated with GLP‐1 tAUC0–30min (r = 0.35, p < 0.02) and tAUC0–120min (r = −0.40, p = 0.04). Conclusions β‐cell function was higher in MORN versus INT chronotypes. Further work is warranted to discern how chronotype impacts insulin secretion. Trial Registration NCT03355469 |
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| ISSN: | 2055-2238 |