Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease

Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease

Abstract Microglia-mediated neuroinflammation plays a crucial role in the progression of Parkinson’s disease (PD). Dysregulation of lipid droplet homeostasis is a significant factor affecting microglial inflammatory responses, but the mechanisms underlying lipid droplet imbalance in PD are currently...

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Bibliographic Details
Main Authors: Chunlei Han, Huizhi Wang, Moxuan Zhang, Liuliu Wu, Anni Wang, Pengda Yang, Yuan Gao, Chaonan Zhang, Jianing Gao, Tao Xue, Tingting Du, Yucheng Ji, Lin Shi, Chunkui Zhang, Renpeng Li, Yilei Xiao, Jianguo Zhang, Fangang Meng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
ACSL1
Parkinson’s disease
Microglia
Lipid droplet
Neuroinflammation
TBK1
Online Access:https://doi.org/10.1186/s12974-025-03517-0
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