Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach
BackgroundAdvances in therapies have significantly improved the outcomes of patients with cancer. However, multidimensional symptoms negatively impact patients’ quality of life. Traditional symptom analysis methods fail to capture the dynamic and interactive nature of these s...
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JMIR Publications
2025-07-01
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| Series: | JMIR Cancer |
| Online Access: | https://cancer.jmir.org/2025/1/e66087 |
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| author | Vincent Richard Allison Gilbert Emanuela Pizzolla Giovanni Briganti |
| author_facet | Vincent Richard Allison Gilbert Emanuela Pizzolla Giovanni Briganti |
| author_sort | Vincent Richard |
| collection | DOAJ |
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BackgroundAdvances in therapies have significantly improved the outcomes of patients with cancer. However, multidimensional symptoms negatively impact patients’ quality of life. Traditional symptom analysis methods fail to capture the dynamic and interactive nature of these symptoms, limiting progress in supportive care. Network analysis (NA) is a promising method to evaluate complex medical situations.
ObjectiveWe performed a systematic review to explore NA’s contribution to understanding the complexity of symptom experiences in patients with cancer.
MethodsThe research question was as follows: “In patients with cancer (population), what is the contribution of NA (intervention) to understanding the complexity of multidimensional symptom experiences (outcome)?” The keywords “network analysis” AND “symptoms” AND “cancer survivors” OR “cancer patients” were searched in MEDLINE, Embase, Google Scholar, and Scopus between 2010 and 2024. Citations were extracted using Covidence software. Two reviewers independently screened the articles and resolved inclusion disagreements through consensus. Data were synthetized, and results have been narratively described. Bias analysis was performed using the Methodological Index for Non-Randomized Studies tool.
ResultsAmong 764 articles initially identified, 22 were included. Studies evaluated mixed solid tumors (n=10), digestive tract cancers (n=4), breast cancer (n=3), head and neck cancer (n=2), gliomas (n=2), and mixed solid and hematological cancers (n=1). Twelve studies used general symptom assessment tools, whereas 10 focused on neuropsychological symptoms. Moreover, 1 study evaluated symptoms at diagnosis, 1 evaluated them during curative radiotherapy, 4 evaluated them during the perioperative period, 5 evaluated them during chemotherapy, 4 evaluated them during ongoing cancer therapies, and 7 evaluated them after acute treatments. Among these, 3 evaluated the longitudinal changes in symptom networks across chemotherapy cycles, and 1 evaluated changes during radiotherapy. Three studies investigated the associations between symptoms and biological parameters. Several NA approaches were used: network visualization (n=1), Bayesian network (n=1), pairwise Markov random field and IsingFit method (n=1), unregularized Gaussian graphical model (n=2), regularized partial correlation network (n=6), network visualization and community NA (n=1), network visualization and Walktrap algorithm (n=1), undirected network model with the Fruchterman-Reingold and edge-betweenness approaches (n=4), biased correlation and concise pattern diagram (n=1), extended Bayesian information criterion graphical LASSO method (n=3), cross-lagged panel network (n=1), and unspecified NA (n=3). Psychological symptoms, particularly anxiety, depression, and distress, were frequently identified as central and stably interconnected. Fatigue consistently emerged as a core symptom, closely linked to sleep disturbances, cognitive impairment, and emotional distress. Associations between symptoms and inflammatory biomarkers (eg, interleukin-6, C-reactive protein, and tumor necrosis factor-α) suggest a biological basis for symptom interconnectivity.
ConclusionsNA consistently identified core symptoms, particularly psychological symptoms and fatigue, and associations with inflammatory biomarkers. NA may deepen the understanding of symptom interconnectivity and guide more effective interventions. However, further longitudinal homogeneous studies using standardized methodologies are needed. |
| format | Article |
| id | doaj-art-04ca9328ae1d418ebfb29ac3d87dc780 |
| institution | Kabale University |
| issn | 2369-1999 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Cancer |
| spelling | doaj-art-04ca9328ae1d418ebfb29ac3d87dc7802025-08-20T03:50:06ZengJMIR PublicationsJMIR Cancer2369-19992025-07-0111e6608710.2196/66087Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis ApproachVincent Richardhttps://orcid.org/0009-0008-3946-6736Allison Gilberthttps://orcid.org/0000-0003-1492-7424Emanuela Pizzollahttps://orcid.org/0009-0004-1159-6505Giovanni Brigantihttps://orcid.org/0000-0002-4038-3363 BackgroundAdvances in therapies have significantly improved the outcomes of patients with cancer. However, multidimensional symptoms negatively impact patients’ quality of life. Traditional symptom analysis methods fail to capture the dynamic and interactive nature of these symptoms, limiting progress in supportive care. Network analysis (NA) is a promising method to evaluate complex medical situations. ObjectiveWe performed a systematic review to explore NA’s contribution to understanding the complexity of symptom experiences in patients with cancer. MethodsThe research question was as follows: “In patients with cancer (population), what is the contribution of NA (intervention) to understanding the complexity of multidimensional symptom experiences (outcome)?” The keywords “network analysis” AND “symptoms” AND “cancer survivors” OR “cancer patients” were searched in MEDLINE, Embase, Google Scholar, and Scopus between 2010 and 2024. Citations were extracted using Covidence software. Two reviewers independently screened the articles and resolved inclusion disagreements through consensus. Data were synthetized, and results have been narratively described. Bias analysis was performed using the Methodological Index for Non-Randomized Studies tool. ResultsAmong 764 articles initially identified, 22 were included. Studies evaluated mixed solid tumors (n=10), digestive tract cancers (n=4), breast cancer (n=3), head and neck cancer (n=2), gliomas (n=2), and mixed solid and hematological cancers (n=1). Twelve studies used general symptom assessment tools, whereas 10 focused on neuropsychological symptoms. Moreover, 1 study evaluated symptoms at diagnosis, 1 evaluated them during curative radiotherapy, 4 evaluated them during the perioperative period, 5 evaluated them during chemotherapy, 4 evaluated them during ongoing cancer therapies, and 7 evaluated them after acute treatments. Among these, 3 evaluated the longitudinal changes in symptom networks across chemotherapy cycles, and 1 evaluated changes during radiotherapy. Three studies investigated the associations between symptoms and biological parameters. Several NA approaches were used: network visualization (n=1), Bayesian network (n=1), pairwise Markov random field and IsingFit method (n=1), unregularized Gaussian graphical model (n=2), regularized partial correlation network (n=6), network visualization and community NA (n=1), network visualization and Walktrap algorithm (n=1), undirected network model with the Fruchterman-Reingold and edge-betweenness approaches (n=4), biased correlation and concise pattern diagram (n=1), extended Bayesian information criterion graphical LASSO method (n=3), cross-lagged panel network (n=1), and unspecified NA (n=3). Psychological symptoms, particularly anxiety, depression, and distress, were frequently identified as central and stably interconnected. Fatigue consistently emerged as a core symptom, closely linked to sleep disturbances, cognitive impairment, and emotional distress. Associations between symptoms and inflammatory biomarkers (eg, interleukin-6, C-reactive protein, and tumor necrosis factor-α) suggest a biological basis for symptom interconnectivity. ConclusionsNA consistently identified core symptoms, particularly psychological symptoms and fatigue, and associations with inflammatory biomarkers. NA may deepen the understanding of symptom interconnectivity and guide more effective interventions. However, further longitudinal homogeneous studies using standardized methodologies are needed.https://cancer.jmir.org/2025/1/e66087 |
| spellingShingle | Vincent Richard Allison Gilbert Emanuela Pizzolla Giovanni Briganti Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach JMIR Cancer |
| title | Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach |
| title_full | Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach |
| title_fullStr | Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach |
| title_full_unstemmed | Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach |
| title_short | Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach |
| title_sort | investigating the complexity of multidimensional symptom experiences in patients with cancer systematic review of the network analysis approach |
| url | https://cancer.jmir.org/2025/1/e66087 |
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