Asymptomatic hyperuricemia and gout: Are there any differences (data from a pilot case-control study)
Asymptomatic hyperuricemia (AH) and gout are characterized by the presence of elevated uric acid (UA) levels. It is not known whether there are differences between these conditions, beyond the acute attacks of arthritis unique to gout.The aim – to identify differences in the frequency of concomitant...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2025-07-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3765 |
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| Summary: | Asymptomatic hyperuricemia (AH) and gout are characterized by the presence of elevated uric acid (UA) levels. It is not known whether there are differences between these conditions, beyond the acute attacks of arthritis unique to gout.The aim – to identify differences in the frequency of concomitant diseases, metabolic disorders and dietary habits in patients with gout and asymptomatic hyperuricemia.Material and methods. A single-stage observational case-control study included 202 people: 101 patients each with AH and gout, matched by age and gender. The examination included collection of anamnesis and medical documentation data on the presence of cardiovascular diseases, type 2 diabetes mellitus (T2DM), nephrolithiasis; inspection and measurement of anthropometric data. The intake of medications was recorded. A survey was conducted regarding the frequency of consumption of meat, seafood and alcohol. Blood levels of glucose, sUA, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), creatinine, cholesterol, C-reactive protein (CRP), and ESR according to Westergren were determined. GFR was calculated using the CKD-EPI formula. All patients underwent ultrasound examination of the knee joints to determine signs of synovitis and deposition of monosodium urate (MSU) crystals.Result. In patients with gout, arterial hypertension (86 (85.1%) vs 53 (52.4%) patients, respectively; p<0.05), T2DM (12 (11.9%) vs 4 (4.0%) patients, respectively; p<0.05) were detected more often than in patients with AH. In the gout group, there were more patients consuming alcohol ≥1 time per week (p=0.02), while there were no differences in the frequency of consumption of meat and seafood. Among patients with gout, there were more participants with GFR<60 ml/min/1.73 m2. In patients with gout, there was a significant direct correlation between the levels of UA and ALT, creatinine, CRP, and an inverse correlation between serum UA and GFR. Ultrasound of the knee joints showed a significantly more frequent deposition of MSU crystals (46 (45.5%) vs 17 (16.8%) patients, respectively; p<0.05) and the presence of synovitis (37 (36.6%) vs 14 (13.8%) patients, respectively; p<0.05) in the gout group.Conclusions. Despite the apparent commonality of gout and AH, they have a number of differences. In gout, arterial hypertension and T2DM are more often detected. Also, in patients with gout, there is a significant direct correlation between the levels of sUA and ALT, creatinine, CRP, while GFR is inversely correlated with the level of serum sUA. Among patients with AH, such correlations were not found. Gout also predicts a statistically more frequent detection of MSU crystal deposits (45.5% vs 31.1% of patients). The intake of meat and fish products did not differ in both groups. |
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| ISSN: | 1995-4484 1995-4492 |