Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer

Abstract Maslinic acid (MA), a pentacyclic triterpenoid, displays broad biological activity including anti-inflammatory, antihyperlipidemic, anti-tumor, cardiovascular protection etc. Our previous study has shown that MA inhibits the proliferation of pancreatic cancer cells via heat shock protein HS...

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Bibliographic Details
Main Authors: Li Cheng, Mingyue Guo, Ammad Ahmad Farooqi, Linlin Wang, Yuxi Zhang, Hanlin Ye, Gan Qiao, Xiukun Lin
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Maslinic acid
Antitumor
HSF1
Ubiquitination-mediated degradation
Autophagy
Online Access:https://doi.org/10.1007/s12672-025-02786-8
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