An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration

An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration

Abstract Despite years of intense investigation, the mechanisms underlying neuronal death in Alzheimer’s disease, remain incompletely understood. To define relevant pathways, we conducted an unbiased, genome-scale forward genetic screen for age-associated neurodegeneration in Drosophila. We also mea...

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Main Authors: Matthew J. Leventhal, Camila A. Zanella, Byunguk Kang, Jiajie Peng, David Gritsch, Zhixiang Liao, Hassan Bukhari, Tao Wang, Ping-Chieh Pao, Serwah Danquah, Joseph Benetatos, Ralda Nehme, Samouil Farhi, Li-Huei Tsai, Xianjun Dong, Clemens R. Scherzer, Mel B. Feany, Ernest Fraenkel
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59654-w
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