Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation
In solid organ transplantation, especially renal transplantation, for the induction of immune tolerance, accumulating evidence has revealed that Regulatory B cells (Breg) play a crucial role in stimulating immune tolerance, alleviating immune responses, and improving graft survival. We describe the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561171/full |
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| author | Jinfeng Liao Yixin Yang Jisong Li Zheng Liu Siyuan Song Yu Zeng Yi Wang Yi Wang |
| author_facet | Jinfeng Liao Yixin Yang Jisong Li Zheng Liu Siyuan Song Yu Zeng Yi Wang Yi Wang |
| author_sort | Jinfeng Liao |
| collection | DOAJ |
| description | In solid organ transplantation, especially renal transplantation, for the induction of immune tolerance, accumulating evidence has revealed that Regulatory B cells (Breg) play a crucial role in stimulating immune tolerance, alleviating immune responses, and improving graft survival. We describe the heterogeneous nature of Bregs, focusing on their defining surface markers and regulatory functions. Meanwhile, the major cytokine secretion function and the correlation between Breg and Treg or other immune checkpoints to balance the immune responses are addressed. Furthermore, we summarized the intrinsic and extrinsic pathways or costimulatory stimuli for the differentiation from naïve B cells. More importantly, we summarized the progression of the immune tolerance induction role of Breg in solid organ (kidney, liver, heart, lung, and islet) transplantation. This is an up-to-date review from the origin of Breg to the function of Breg in solid organ transplantation and how it induces immune tolerance in both murine models and human solid organ transplantation. |
| format | Article |
| id | doaj-art-04a8a4eb754242ebb80858d01034e48d |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-04a8a4eb754242ebb80858d01034e48d2025-08-20T02:08:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15611711561171Regulatory B cells, the key regulator to induce immune tolerance in organ transplantationJinfeng Liao0Yixin Yang1Jisong Li2Zheng Liu3Siyuan Song4Yu Zeng5Yi Wang6Yi Wang7Department of Dermatology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Clinical Medicine, The First Clinical Medical College of Norman Bethune University of Medical Sciences, Jilin, ChinaDepartment of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Pathology, MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, United StatesDepartment of Hyperbaric Oxygen, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaTranslational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaIn solid organ transplantation, especially renal transplantation, for the induction of immune tolerance, accumulating evidence has revealed that Regulatory B cells (Breg) play a crucial role in stimulating immune tolerance, alleviating immune responses, and improving graft survival. We describe the heterogeneous nature of Bregs, focusing on their defining surface markers and regulatory functions. Meanwhile, the major cytokine secretion function and the correlation between Breg and Treg or other immune checkpoints to balance the immune responses are addressed. Furthermore, we summarized the intrinsic and extrinsic pathways or costimulatory stimuli for the differentiation from naïve B cells. More importantly, we summarized the progression of the immune tolerance induction role of Breg in solid organ (kidney, liver, heart, lung, and islet) transplantation. This is an up-to-date review from the origin of Breg to the function of Breg in solid organ transplantation and how it induces immune tolerance in both murine models and human solid organ transplantation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561171/fullregulatory B cells (Breg)interleukin-10 (IL-10)solid organ transplantationchemokinesB cell differentiationimmune tolerance |
| spellingShingle | Jinfeng Liao Yixin Yang Jisong Li Zheng Liu Siyuan Song Yu Zeng Yi Wang Yi Wang Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation Frontiers in Immunology regulatory B cells (Breg) interleukin-10 (IL-10) solid organ transplantation chemokines B cell differentiation immune tolerance |
| title | Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation |
| title_full | Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation |
| title_fullStr | Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation |
| title_full_unstemmed | Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation |
| title_short | Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation |
| title_sort | regulatory b cells the key regulator to induce immune tolerance in organ transplantation |
| topic | regulatory B cells (Breg) interleukin-10 (IL-10) solid organ transplantation chemokines B cell differentiation immune tolerance |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561171/full |
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